TRIM35 - tripartite motif containing 35 Gene

Also Known as HLS5; MAIR

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 23087

About TRIM35

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:27,284,886-27,311,272 (from NCBI)

This gene has 4 transcripts (splice variants), 121 orthologues and 80 paralogues. Ubiquitous expression in skin (RPKM 5.7), testis (RPKM 5.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]

TRIM35 Products (3)

mRNA Protein Name
NM_001304495.2 NP_001291424.1 E3 ubiquitin-protein ligase TRIM35 isoform 2
NM_001362813.2 NP_001349742.1 E3 ubiquitin-protein ligase TRIM35 isoform 3
NM_171982.5 NP_741983.2 E3 ubiquitin-protein ligase TRIM35 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in innate immune response IDA
IDA: Inferred from direct assay
18248090 GOA
involved in negative regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
14662771 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
14662771 GOA
involved in suppression of viral release by host IDA
IDA: Inferred from direct assay
18248090 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM35 Protein Structure

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (21 - 60)

zf-B_box

zf-B_box: B-box zinc finger (99 - 137)

PRY

PRY: SPRY-associated domain (305 - 351)

SPRY

SPRY: SPRY domain (353 - 468)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM35

  • hemopoietic lineage switch protein 5

関連疾患

Diseases Alias
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

  • Glomerulonephritis With Sparse Hair And Telangiectases

  • Telangiectatic Membranoproliferative Glomerulonephritis

  • HLTRS

  • Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

  • Hlt-Renal Defect Syndrome

  • Glomerulonephritis Sparse Hair Telangiectases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-183629 ZNF281-IN-1 / Unkown
HY-RS15039 TRIM35 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21209 Trim35 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27725 Trim35 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta TRIM35 VGNC VGNC:79026
Rattus norvegicus TRIM35 RGD RGD:1564642
Felis catus TRIM35 VGNC VGNC:66535
Canis familiaris TRIM35 VGNC VGNC:47816
Mus musculus TRIM35 MGD MGI:1914104
Bos taurus TRIM35 VGNC VGNC:36330
Others TRIM35 NCBI