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Cat. No.: HY-183629

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ZNF281-IN-1

ZNF281-IN-1 is a ZNF281 inhibitor. ZNF281-IN-1 disrupts the binding of transcriptionally active DNA-bound ZNF281 to the promoters of target genes including TRIM35 and ZEB1. ZNF281-IN-1 inhibits tumor cell proliferation, stabilizes P53 and upregulates PUMA to induce apoptosis, while triggering cellular senescence. ZNF281-IN-1 completely prevents Doxorubicin (HY-15142A)-induced cardiotoxicity (AIC), and enhances rather than impairs the antitumor efficacy of Doxorubicin. ZNF281-IN-1 completely blocks the distant metastasis of melanoma to the lungs. ZNF281-IN-1 can be used in the research of cardiotoxicity, lung cancer and metastatic melanoma.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₃F₆NO₃S₂
Molecular Weight:493.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZNF281-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

In Vitro

ZNF281-IN-1 (Compound ZIM) inhibits proliferation, induces apoptosis, and promotes senescence in A549 non-small cell lung cancer cells by activating the P53-PUMA pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZNF281-IN-1 (Compound ZIM) (100 mg/kg; once daily for 10 weeks) completely prevents Doxorubicin-induced cardiac dysfunction. Its inhibitory effect on the growth of A549 lung cancer tumors is comparable to that of Doxorubicin, and it enhances tumor regression when used in combination with doxorubicin^[1].
ZNF281-IN-1 (100 mg/kg; once daily for 10 weeks) inhibits tumor growth of primary metastatic melanoma and completely prevents lung metastasis in orthotopic mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 493.44
Formula C₂₀H₁₃F₆NO₃S₂
SMILES

COC1=C(C=CC(/C=C2SC(NC\2=O)=S)=C1)OCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lorenzana-Carrillo MA, et al. Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology. Sci Transl Med. 2026;18(845):eadz7727. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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