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N4BP3 - NEDD4 binding protein 3 Gene

Also Known as LZTS4

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23138

About N4BP3

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:178,113,532-178,127,034 (from NCBI)

This gene has 1 transcript (splice variant) and 197 orthologues. Broad expression in placenta (RPKM 5.5), esophagus (RPKM 3.2) and 20 other tissues.

Summary

Predicted to be involved in nervous system development. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

N4BP3 Products (1)

mRNA	Protein	Name
NM_015111.2	NP_055926.1	NEDD4-binding protein 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IDA IDA: Inferred from direct assay	34880843	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26496610	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of positive effect innate immune response	IDA IDA: Inferred from direct assay	23951545	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

N4BP3 Protein Structure

Fez1

0
100
200
300
400
500
544 a.a.

Protein Preferred Names	Protein Names
NEDD4-binding protein 3

N4BP3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	N4BP3	O15049	CNKSR3	Homo sapiens	Q6P9H4	Validated Y2H	32296183
Intra	N4BP3	O15049	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	N4BP3	O15049	PRR35	Homo sapiens	P0CG20	Validated Y2H	32296183
Intra	N4BP3	O15049	CCDC17	Homo sapiens	Q96LX7-5	Validated Y2H	32296183
Intra	N4BP3	O15049	RNF41	Homo sapiens	Q9H4P4	Validated Y2H	32296183
Intra	N4BP3	O15049	LMO4	Homo sapiens	P61968	Validated Y2H	32296183
Intra	N4BP3	O15049	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	N4BP3	O15049	RFC5	Homo sapiens	P40937	Validated Y2H	32296183
Intra	N4BP3	O15049	UBASH3A	Homo sapiens	P57075-2	Validated Y2H	32296183
Intra	N4BP3	O15049	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	N4BP3	O15049	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	N4BP3	O15049	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Developmental And Epileptic Encephalopathy 5	Epileptic Encephalopathy, Early Infantile, 5 DEE5 Eiee5 Developmental And Epileptic Encephalopathy, 5 Early Infantile Epileptic Encephalopathy 5 Encephalopathy, Epileptic, Early Infantile, Type 5
Developmental And Epileptic Encephalopathy 4	DEE4 Epileptic Encephalopathy, Early Infantile, 4 Eiee4 Early Infantile Epileptic Encephalopathy 4 Stxbp1-Related Early-Onset Encephalopathy Early Myoclonic Encephalopathy Developmental And Epileptic Encephalopathy, 4 Stxbp1 Disorders Stxbp1 Encephalopathy Developmental And Epileptic Encephalopathy, Type 4 Early-Infantile Epileptic Encephalopathy 4 Stxbp1 Encephalopathy With Epilepsy Stxbp1 Epileptic Encephalopathy Stxbp1-Related Developmental And Epileptic Encephalopathy Stxbp1-Related Epileptic Encephalopathy Eme Neonatal Epilepsy With Suppression-Burst Pattern Encephalopathy, Epileptic, Early Infantile, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS08983	N4BP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	N4BP3	RGD	RGD:1308356
Macaca mulatta	N4BP3	VGNC	VGNC:75053
Bos taurus	N4BP3	VGNC	VGNC:31853
Canis familiaris	N4BP3	VGNC	VGNC:43598
Felis catus	N4BP3	VGNC	VGNC:102262
Mus musculus	N4BP3	MGD	MGI:2442218
Others	N4BP3	NCBI