Acvr2b - activin A receptor type 2B Gene
生物種: Rattus norvegicus
About Acvr2b
This gene has 2 transcripts (splice variants), 259 orthologues, 11 paralogues and is associated with 5 phenotypes. Biased expression in Muscle (RPKM 28.7), Kidney (RPKM 21.8) and 9 other tissues.
Summary
Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (Activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]
Acvr2b Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_031554.1 | NP_113742.1 | activin receptor type-2B precursor |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables activin binding |
IDA
IDA: Inferred from direct assay
|
12385827 | RGD |
| enables inhibin binding |
IDA
IDA: Inferred from direct assay
|
12385827 | RGD |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in adrenal gland development |
IEP
IEP: Inferred from expression pattern
|
12844345 | RGD |
| involved in response to activity |
IEP
IEP: Inferred from expression pattern
|
22332899 | RGD |
Acvr2b Protein Structure
Activin_recp: pfam01064 (49 - 118)
STKc_ACVR2b: cd14140 (226 - 516)
- 0
- 100
- 200
- 300
- 400
- 500
- 545 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
activin receptor type-2B |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| 製品番号 | 製品名 |
製品効果
|
純度 |
Rare Diseases
|
|---|---|---|---|---|
| HY-P99355 | Bimagrumab (WT IgG1) | Inhibitor | 99.31% | Unkown |
| HY-185430 | HM-279 | Inhibitor | / | Unkown |
| HY-W1142089 | ActRIIB-IN-2 | Inhibitor | / | Unkown |
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