PLEK2 - pleckstrin 2 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 26499

About PLEK2

Cytogenetic location: 14q23.3-q24.1 Genomic coordinates (GRCh38): 14:67,386,984-67,412,165 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 16.6), small intestine (RPKM 14.3) and 17 other tissues.

Summary

The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin Cytoskeleton to induce cell spreading. In conjunction with Complement Component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]

PLEK2 Products (1)

mRNA Protein Name
NM_016445.3 NP_057529.1 pleckstrin-2

PLEK2 Protein Structure

PH

PH: PH domain (6 - 99)

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (142 - 223)

PH

PH: PH domain (248 - 353)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

pleckstrin-2

  • pleckstrin 2 homolog

関連疾患

Diseases Alias
Ecthyma
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10678 PLEK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22732 Plek2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29246 Plek2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus PLEK2 VGNC VGNC:33002
Rattus norvegicus PLEK2 RGD RGD:1305786
Mus musculus PLEK2 MGD MGI:1351466
Macaca mulatta PLEK2 VGNC VGNC:76071
Canis familiaris PLEK2 VGNC VGNC:51670
Felis catus PLEK2 VGNC VGNC:64215
Others PLEK2 NCBI