HRG - histidine rich glycoprotein Gene

Also Known as HPRG; HRGP; THPH11

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3273

About HRG

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,666,014-186,678,234 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1677.7).

Summary

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

HRG Products (1)

mRNA Protein Name
NM_000412.5 NP_000403.1 histidine-rich glycoprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables heme binding IDA
IDA: Inferred from direct assay
678554 GOA
enables heparan sulfate proteoglycan binding IDA
IDA: Inferred from direct assay
15138272 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
16436387 GOA
enables immunoglobulin binding IDA
IDA: Inferred from direct assay
10514432 GOA
enables metal ion binding IDA
IDA: Inferred from direct assay
678554 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11134179 GOA
enables signaling receptor binding IDA
IDA: Inferred from direct assay
16436387 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
15138272 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
18797515 GOA
involved in cytolysis by host of symbiont cells IDA
IDA: Inferred from direct assay
18797515 GOA
involved in defense response to fungus IDA
IDA: Inferred from direct assay
18797515 GOA
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
14744774 GOA
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
14744774 GOA
involved in negative regulation of cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
16489009 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
21215706 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
14744774 GOA
involved in negative regulation of endothelial cell chemotaxis IDA
IDA: Inferred from direct assay
14744774 GOA
involved in negative regulation of lamellipodium assembly IDA
IDA: Inferred from direct assay
16489009 GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway IDA
IDA: Inferred from direct assay
16489009 GOA
involved in platelet activation IDA
IDA: Inferred from direct assay
19903770 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
14744774 GOA
involved in positive regulation of blood vessel remodeling IDA
IDA: Inferred from direct assay
21215706 GOA
involved in positive regulation of focal adhesion assembly IDA
IDA: Inferred from direct assay
14744774 GOA
involved in positive regulation of immune response to tumor cell IDA
IDA: Inferred from direct assay
21215706 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: Inferred from direct assay
16489009 GOA
involved in regulation of blood coagulation IDA
IDA: Inferred from direct assay
6740558 GOA
involved in regulation of gene expression IDA
IDA: Inferred from direct assay
21215706 GOA
involved in regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
16489009 GOA
involved in regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
16489009 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cell surface IDA
IDA: Inferred from direct assay
15220341 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
18797515 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HRG Protein Structure

Cystatin

Cystatin: Cystatin domain (23 - 95)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

histidine-rich glycoprotein

  • histidine-proline-rich glycoprotein

HRG Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
HRG P04196 RGS20 Homo sapiens O76081-6
Y2H Prey Pooling
32296183
Intra
HRG P04196 RGS20 Homo sapiens O76081-6
Y2H Array
32296183
Intra
HRG P04196 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
HRG P04196 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross
HRG P04196 q99xu0_strp1 Streptococcus pyogenes serotype M1 Q99XU0
ITC
24825900
Intra
HRG P04196 RCHY1 Homo sapiens Q96PM5
Confocal
21988832
Intra
HRG P04196 RCHY1 Homo sapiens Q96PM5
Y2H
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HRG Proteins

製品番号 製品名 アクセッション番号 純度
HY-P77380 HPRG Protein, Human (HEK293, His) P04196/NP_000403.1 (V19-K525) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

関連疾患

Diseases Alias
Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency

  • THPH11

  • Thrombophilia 11 Due To Hrg Deficiency
Thrombophilia Due To Hrg Deficiency

  • Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency

  • Hereditary Thrombophilia Due To Congenital Hrg Deficiency

  • Thph11
Thrombophilia

  • Hypercoagulability State
Protein C Deficiency

  • Hereditary Thrombophilia Due To Protein C Deficiency

  • Proc Deficiency

  • Congenital Thrombotic Disease, Due To Protein C Deficiency
Thrombosis

  • Thrombosis Of Blood Vessel
Prothrombin Thrombophilia

  • Prothrombin G20210a Thrombophilia

  • Hyperprothrombinemia
Thrombophilia Due To Thrombin Defect

  • Venous Thromboembolism

  • Venous Thrombosis

  • Thrombophilia Due To Factor 2 Defect

  • Thromboembolism

  • THPH1

  • Thromboembolism, Susceptibility To

  • Venous Thromboembolism, Susceptibility To

  • Venous Thrombosis, Protection Against

  • Prothrombin-Related Thrombophilia

  • Hyperprothrombinemia

  • Venous Thrombosis, Susceptibility To

  • Thrombophilia 1 Due To Thrombin Defect

  • F2-Related Thrombophilia

  • Factor Ii-Related Thrombophilia

  • Prothrombin 20210g>A Thrombophilia

  • Prothrombin G20210a Thrombophilia

  • Prothrombin Thrombophilia
Corneal Neovascularization

  • Corneal Neovascularisation

  • Corneal Vascularisation

  • Extensive Superficial Corneal Vascularisation
Plasminogen Deficiency, Type I

  • Hypoplasminogenemia

  • Dysplasminogenemia

  • Plasminogen Deficiency Type I

  • Congenital Plasminogen Deficiency

  • Ligneous Conjunctivitis

  • Type 1 Plasminogen Deficiency

  • Plasminogen Deficiency Type 1

  • Plasminogen Deficiency

  • PLGD

  • Plasminogen Deficiency Type Ii

  • Deficiency, Plasminogen, Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06358 HRG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176070 HRG038 Inhibitor / Unkown
HY-RS16312 NRG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16611 Nrg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16937 Hrg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23380 Hrg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus HRG MGD MGI:2146636
Rattus norvegicus HRG RGD RGD:619808
Macaca mulatta HRG VGNC VGNC:73521
Canis familiaris HRG VGNC VGNC:41785
Felis catus HRG VGNC VGNC:67648
Bos taurus HRG VGNC VGNC:29953
Others HRG NCBI