MIEF1 - mitochondrial elongation factor 1 Gene

Also Known as MID51; L0R8F8; SMCR7L; AltMIEF1; HSU79252; MIEF1-MP; dJ1104E15.3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 54471

About MIEF1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,500,100-39,518,132 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 13.7), kidney (RPKM 8.6) and 25 other tissues.

Summary

Enables ADP binding activity; GDP binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of mitochondrial fission; positive regulation of mitochondrial translation; and positive regulation of protein targeting to membrane. Located in mitochondrial matrix and mitochondrial outer membrane. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]

MIEF1 Products (2)

mRNA	Protein	Name
NM_001304564.2	NP_001291493.1	mitochondrial dynamics protein MID51 isoform 2
NM_019008.6	NP_061881.2	mitochondrial dynamics protein MID51 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables ADP binding	IDA IDA: Inferred from direct assay	24515348	GOA
enables GDP binding	IDA IDA: Inferred from direct assay	24515348	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21701560	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in mitochondrial fission	IMP IMP: Inferred from mutant phenotype	21701560	GOA
NOT involved in mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	23921378	GOA
involved in positive regulation of mitochondrial fission	IDA IDA: Inferred from direct assay	23283981	GOA
involved in positive regulation of mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	33632269	GOA
NOT involved in positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	23921378	GOA
involved in positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	23283981	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	21508961	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23921378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIEF1 Protein Structure

Mab-21

0
100
200
300
400
463 a.a.

Protein Preferred Names	Protein Names
mitochondrial dynamics protein MID51	MIEF1 microprotein

MIEF1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MIEF1	Q9NQG6	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	MIEF1	Q9NQG6	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	MIEF1	Q9NQG6	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	CMTM6	Homo sapiens	Q9NX76	Validated Y2H	32296183
Intra	MIEF1	Q9NQG6	CMTM6	Homo sapiens	Q9NX76	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	CMTM6	Homo sapiens	Q9NX76	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	TPD52	Homo sapiens	P55327-2	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	TPD52	Homo sapiens	P55327-2	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	HTATIP2	Homo sapiens	Q9BUP3-3	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	HTATIP2	Homo sapiens	Q9BUP3-3	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	FAM25C	Homo sapiens	B3EWG5	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	FAM25C	Homo sapiens	B3EWG5	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	PRAF2	Homo sapiens	O60831	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	PRAF2	Homo sapiens	O60831	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	ATP5PF	Homo sapiens	P18859	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	ATP5PF	Homo sapiens	P18859	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	ABHD5	Homo sapiens	Q8WTS1	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	ABHD5	Homo sapiens	Q8WTS1	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	ARL6IP5	Homo sapiens	O75915	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	ARL6IP5	Homo sapiens	O75915	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	FIS1	Homo sapiens	Q9Y3D6	Anti Tag CoIP	21701560
Intra	MIEF1	Q9NQG6	FIS1	Homo sapiens	Q9Y3D6	IF	21701560
Intra	MIEF1	Q9NQG6	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	MED21	Homo sapiens	Q13503	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	MED21	Homo sapiens	Q13503	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	ARFIP2	Homo sapiens	P53365	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	DNM1L	Homo sapiens	O00429	IF	21701560
Intra	MIEF1	Q9NQG6	DNM1L	Homo sapiens	O00429	Anti Tag CoIP	21701560
Intra	MIEF1	Q9NQG6	PLIN3	Homo sapiens	O60664	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	PLIN3	Homo sapiens	O60664	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	PRR4	Homo sapiens	Q16378	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	PRR4	Homo sapiens	Q16378	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	MAGEA1	Homo sapiens	P43355	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	MAGEA1	Homo sapiens	P43355	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	MIEF1	Q9NQG6	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	MAL2	Homo sapiens	Q969L2	Y2H Array	32296183
Intra	MIEF1	Q9NQG6	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	MIEF1	Q9NQG6	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	MIEF1	Q9NQG6	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Encephalopathy Due To Defective Mitochondrial And Peroxisomal Fission 1	Encephalopathy, Lethal, Due To Defective Mitochondrial Peroxisomal Fission 1 EMPF1 Empf Dnm1l-Related Encephalopathy Due To Mitochondrial And Peroxisomal Fission Defect Encephalopahty, Lethal, Due To Defective Mitochondrial Peroxisomal Fission Encephalopahty, Lethal, Due To Defective Mitochondrial Peroxisomal Fission 1 Encephalopathy, Lethal, Due To Defective Mitochondrial And Peroxisomal Fission
Myopathy, Centronuclear, 1	Autosomal Dominant Centronuclear Myopathy CNM1 Centronuclear Myopathy 1 Ad-Cnm Myopathy, Centronuclear, Autosomal Dominant Myotubular Myopathy, Autosomal Dominant Centronuclear Myopathy, Autosomal, Modifier Of Autosomal Dominant Myotubular Myopathy Dnm2-Related Centronuclear Myopathy Centronuclear Myopathy Autosomal Dominant Myopathies, Structural, Congenital Myopathy, Centronuclear, Type 1
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS08439	MIEF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	MIEF1	VGNC	VGNC:43226
Rattus norvegicus	MIEF1	RGD	RGD:1359173
Bos taurus	MIEF1	VGNC	VGNC:31467
Mus musculus	MIEF1	MGD	MGI:2146020
Felis catus	MIEF1	VGNC	VGNC:63498
Macaca mulatta	MIEF1	VGNC	VGNC:74832
Others	MIEF1	NCBI