SCYL2 - SCY1 like pseudokinase 2 Gene

Also Known as AMC4; AMCNACC; CVAK104

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 55681

About SCYL2

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:100,267,177-100,341,715 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 12.7), esophagus (RPKM 10.5) and 25 other tissues.

Summary

The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting Frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

SCYL2 Products (5)

mRNA	Protein	Name
NM_001317784.2	NP_001304713.1	SCY1-like protein 2 isoform 1
NM_001330253.2	NP_001317182.1	SCY1-like protein 2 isoform 2
NM_001330254.2	NP_001317183.1	SCY1-like protein 2 isoform 2
NM_001330256.2	NP_001317185.1	SCY1-like protein 2 isoform 3
NM_017988.6	NP_060458.3	SCY1-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	19643732	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	19643732	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	19643732	GOA
involved in endosome to lysosome transport	IDA IDA: Inferred from direct assay	19643732	GOA
acts upstream of negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19643732	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	19643732	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCYL2 Protein Structure

Pkinase

0
200
400
600
800
929 a.a.

Protein Preferred Names	Protein Names
SCY1-like protein 2	SCY1-like 2

SCYL2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SCYL2	Q6P3W7	FZD5	Homo sapiens	Q13467	Anti Tag CoIP	19643732
Intra	SCYL2	Q6P3W7	DVL1	Homo sapiens	O14640	Anti Tag CoIP	19643732

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Arthrogryposis Multiplex Congenita 4, Neurogenic, With Agenesis Of The Corpus Callosum	Arthrogryposis Multiplex Congenita, Neurogenic, With Agenesis Of The Corpus Callosum AMC4 Amcnacc Zain Syndrome
Arthrogryposis Multiplex Congenita-4	Zain Syndrome
Geroderma Osteodysplasticum	Gerodermia Osteodysplastica Geroderma Osteodysplastica GO Walt Disney Dwarfism Type Of Gerodermia Osteodysplastica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS02083	CCL14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12576	SCYL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	SCYL2	VGNC	VGNC:100102
Canis familiaris	SCYL2	VGNC	VGNC:45939
Bos taurus	SCYL2	VGNC	VGNC:34375
Mus musculus	SCYL2	MGD	MGI:1289172
Rattus norvegicus	SCYL2	RGD	RGD:1305665
Felis catus	SCYL2	VGNC	VGNC:64941
Others	SCYL2	NCBI