country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DDI2 - DNA damage inducible 1 homolog 2 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 84301

About DDI2

This gene has 6 transcripts (splice variants), 164 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 7.7), kidney (RPKM 5.8) and 25 other tissues.

Summary

Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DDI2 Products (1)

mRNA	Protein	Name
NM_032341.5	NP_115717.3	protein DDI1 homolog 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	27528193	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	27461074	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27528193	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	27461074	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	27528193	GOA
involved in protein processing	IMP IMP: Inferred from mutant phenotype	27676298	GOA
involved in regulation of DNA stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDI2 Protein Structure

ubiquitin

Asp_protease

0
100
200
300
399 a.a.

Protein Preferred Names	Protein Names
protein DDI1 homolog 2	DDI1, DNA-damage inducible 1, homolog 2

Diseases	Alias
Ngly1-Deficiency	Deficiency Of N-Glycanase 1 Ngly1-Cddg Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome Ngly1 Deficiency Congenital Disorder Of Deglycosylation Congenital Disorder Of Glycosylation Type Iv Congenital Disorder Of Deglycosylation Cddg Congenital Disorder Of Glycosylation Type Iv Cdg1v
Ruijs-Aalfs Syndrome	Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome RJALS
Combat Disorder	Combat Disorders Combat Neurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03612	DDI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	DDI2	MGD	MGI:1917244
Rattus norvegicus	DDI2	RGD	RGD:1311815
Canis familiaris	DDI2	VGNC	VGNC:52126
Others	DDI2	NCBI