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ALG10 - ALG10 alpha-1,2-glucosyltransferase Gene

Also Known as DIE2; KCR1; ALG10A

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 84920

About ALG10

Cytogenetic location: 12p11.1 Genomic coordinates (GRCh38): 12:34,022,377-34,028,302 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 2.3), thyroid (RPKM 2.0) and 25 other tissues.

Summary

This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]

ALG10 Products (1)

mRNA	Protein	Name
NM_032834.4	NP_116223.3	dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALG10 Protein Structure

DIE2_ALG10

0
100
200
300
400
473 a.a.

Protein Preferred Names	Protein Names
dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase	alpha-1,2-glucosyltransferase ALG10-A

ALG10 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ALG10	Q5BKT4	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	ALG10	Q5BKT4	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	ALG10	Q5BKT4	HERPUD2	Homo sapiens	Q9BSE4	Y2H Prey Pooling	32296183
Intra	ALG10	Q5BKT4	HERPUD2	Homo sapiens	Q9BSE4	Y2H Array	32296183
Intra	ALG10	Q5BKT4	HERPUD2	Homo sapiens	Q9BSE4	Validated Y2H	32296183
Intra	ALG10	Q5BKT4	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	ALG10	Q5BKT4	SERP2	Homo sapiens	Q8N6R1	Y2H Prey Pooling	32296183
Intra	ALG10	Q5BKT4	SERP2	Homo sapiens	Q8N6R1	Y2H Array	32296183
Intra	ALG10	Q5BKT4	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	ALG10	Q5BKT4	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	ALG10	Q5BKT4	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	ALG10	Q5BKT4	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	ALG10	Q5BKT4	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Toxic Myocarditis
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS00587	ALG10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	ALG10	RGD	RGD:708500
Mus musculus	ALG10	MGD	MGI:2146159
Others	ALG10	NCBI