GRK6/Aurora A-IN-1
Based on 3 publication(s) in Google Scholar
GRK6/Aurora A-IN-1 is a dual inhibitor of G protein-coupled receptor kinase 6 (GRK6)/Aurora A, with IC50 values of 120 nM and 11 nM, respectively. GRK6 is a key kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for research on multiple myeloma.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.98%
- CAS 番号: 2677786-27-3
- 分子式: C21H21FN6
- 分子量:376.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 GRK6/Aurora A-IN-1
MoreAurora Kinase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
GRK6 120 nM (IC50) |
Aurora A 11 nM (IC50) |
体外実験
GRK6-IN-2 (Compound 10a) (10 μM; 80 min) potently inhibits GRK6 in biochemical assays, with an IC50 of 120 nM[1].
GRK6-IN-2 (10 μM) inhibits Aurora A in biochemical assays, with an IC50 value of 11 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 2677786-27-3
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性状 Solid
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分子量 376.43
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分子式 C21H21FN6
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Color White to off-white
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SMILES
C[C@H](NC1=NC(NC2=NNC(CC)=C2)=C3C=CC=CC3=N1)C4=CC=C(F)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
2026 Feb 26. PMID: 41748625 -
Commun Biol
Cell-based and isoform-selective G protein-coupled receptor kinase assays for comprehensive inhibitor evaluation. [Abstract]2026 Jan 16;9(1):287. PMID: 41545717 -
iScience
2024 May 22;27(6):110047. PMID: 38883814
溶剤 & 溶解度
体外:
Methanol : ≥ 125 mg/mL (332.07 mM)
DMSO : ≥ 100 mg/mL (265.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Methanol | 1 mM | 2.6565 mL | 13.2827 mL | 26.5654 mL | 66.4134 mL |
| 5 mM | 0.5313 mL | 2.6565 mL | 5.3131 mL | 13.2827 mL | |
| 10 mM | 0.2657 mL | 1.3283 mL | 2.6565 mL | 6.6413 mL | |
| 15 mM | 0.1771 mL | 0.8855 mL | 1.7710 mL | 4.4276 mL | |
| 20 mM | 0.1328 mL | 0.6641 mL | 1.3283 mL | 3.3207 mL | |
| 25 mM | 0.1063 mL | 0.5313 mL | 1.0626 mL | 2.6565 mL | |
| 30 mM | 0.0886 mL | 0.4428 mL | 0.8855 mL | 2.2138 mL | |
| 40 mM | 0.0664 mL | 0.3321 mL | 0.6641 mL | 1.6603 mL | |
| 50 mM | 0.0531 mL | 0.2657 mL | 0.5313 mL | 1.3283 mL | |
| 60 mM | 0.0443 mL | 0.2214 mL | 0.4428 mL | 1.1069 mL | |
| 80 mM | 0.0332 mL | 0.1660 mL | 0.3321 mL | 0.8302 mL | |
| 100 mM | 0.0266 mL | 0.1328 mL | 0.2657 mL | 0.6641 mL |
GRK6/Aurora A-IN-1 関連分類
HY-142817 関連分類
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