2677786-27-3
Chemical Structure
GRK6/Aurora A-IN-1
- CAS No.: 2677786-27-3
- Formula:C21H21FN6
- Molecular Weight:376.43
IUPAC Name: (8R,9S,13S,14S)-3-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one-6,6,7,7,11-d5
InChIKey: QIKJAWWGNVSEHB-ZDUSSCGKSA-N
SMILES: C[C@H](NC1=NC(NC2=NNC(CC)=C2)=C3C=CC=CC3=N1)C4=CC=C(F)C=C4
Biological Activity: GRK6/Aurora A-IN-1 is a dual inhibitor of G protein-coupled receptor kinase 6 (GRK6)/Aurora A, with IC50 values of 120 nM and 11 nM, respectively. GRK6 is a key kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for research on multiple myeloma[1].
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GRK6/Aurora A-IN-1 | 98.98% | GRK6/Aurora A-IN-1 is a dual inhibitor of G protein-coupled receptor kinase 6 (GRK6)/Aurora A, with IC50 values of 120 nM and 11 nM, respectively. GRK6 is a key kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for research on multiple myeloma. | ||||||||||||||||||||
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Keywords
