H77-77
H77-77 is a selective MAO-A inhibitor with blood-brain barrier permeability, exhibiting an IC50 of 7.4 μM against rat MAO-A. H77-77 accumulates via uptake by serotonergic and noradrenergic neurons. H77-77 releases norepinephrine and serotonin from intracellular neuronal storage sites. H77-77 can be used in studies related to neurological disorders.
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- CAS 番号: 21618-99-5
- 分子式: C10H15NO
- 分子量:165.24
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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rMAO-A 7.4 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 160-200 g)[1]
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Dosage:1.25 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
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Administration:s.c.
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Result:Produced 35% inhibition of MAO inside serotonergic neurons in the hypothalamus, with minimal inhibition outside these neurons at 1.25 mg/kg s.c.
Produced 78% inhibition of MAO inside serotonergic neurons and 15% inhibition outside these neurons, and 60% inhibition inside noradrenergic neurons and 11% inhibition outside these neurons at 10 mg/kg s.c.
Reduced MAO inhibition inside serotonergic neurons to 27% at the 10 mg/kg s.c. dose when pretreated with norzimeldine.
Reduced MAO inhibition inside noradrenergic neurons to 20% at the 10 mg/kg s.c. dose when pretreated with CPP199.
Showed no selective inhibition of MAO inside dopaminergic neurons in the striatum.
化学情報
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CAS 番号 21618-99-5
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分子量 165.24
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分子式 C10H15NO
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SMILES
OC1=CC(=CC=C1C)CC(N)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Fagervall I, et al. Selective inhibition by 4,alpha-dimethyl-m-tyramine (H77/77) and 4-methyl-alpha-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. 1988 Aug;338(2):143-7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
H77-77 関連分類
HY-124331 関連分類
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