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製品番号: HY-P2995

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ヘモグロビン

(別名: Hemoglobin)

4 Cited Publications

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 9008-02-0

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hemoglobin 構造式

CAS 番号: 9008-02-0

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Heme Oxygenase (HO) アイソフォーム固有の製品をすべて表示 :

HO-1
HO-2

体外実験

Hemoglobin (1-50 μM, 6 h) increases α1-microglobulin and reactive oxygen species in HepG2 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Hemoglobin (300 mg/k, i.v. at 16 h before LPS) provides protection against LPS induced lethal endotoxemia in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS induced endotoxemia rat model^[2]
Dosage:

300 mg/kg
Administration:

i.v., at 16 h before LPS treatment (40 mg/kg, i.v,)
Result:

Increased rat survival.
Showed significant attenuation of neutrophil alveolitis ( > 80 %) at 24 h after LPS injection.
Increased HO-1 expression and activity in rat lung.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 9008-02-0
性状 Solid
Color Brown to reddish brown
SMILES

[Hemoglobin]
別名

Hemoglobin
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

All Flow CytometryWBBio/Physico-chemical AssayCell Imaging/Staining

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Journal Impact Factor

Int J Biol Macromol

Dynamic catalytic domain plasticity governs substrate specificity in industrial serine proteases: Structural and functional implications. [Abstract]

2025 Oct 17;331(Pt 1):148374. PMID: 41110577
Photonics Res

2025.
Antioxid Redox Signal

Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage. [Abstract]

2025 Dec 26. PMID: 41468154

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Flow cytometry by Annexin V-APC:7-AAD staining and analysis of apoptosis rate. Hemoglobin (HB) (30 μM; 24 h) treatment increased the percentage of apoptotic cells in HT22 mouse hippocampal neuronal cells, as indicated by higher Annexin V-APC+/7-AAD-cells.

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Western blotting images and quantitative data of relative expression levels of 4-hydroxynonenal (4-HNE), BAX, BCL-2, and cleaved caspase-3 were presented. Hemoglobin (HB) (30 μM; 24 h) treatment upregulated levels of 4-hydroxynonenal (4-HNE), proapoptotic proteins Bax and cleaved caspase-3 while downregulated the antiapoptotic protein BCL-2.

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Hemoglobin (HB) (30 μM; 24 h) exposure led to marked increases in MDA, hydrogen peroxide and decreased superoxide dismutase (SOD) activity.

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Hemoglobin (HB) (30 μM; 24 h) caused the mitochondrial outer membranes to become denser, with some showing rupture, and reduced or eliminated cristae, and induced vacuolization and the occasional formation of autophagic vesicles.

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Western blotting images and quantitative data of relative expression levels of p62, PINK1, PARKIN, and LC3II/I were presented. Hemoglobin (HB) (30 μM; 24 h) increased the LC3-II/I ratio and the levels of PINK1, p62, and Parkin, indicating impaired autophagic flux and enhanced mitophagy activity.
Int Immunopharmacol

The mechanism study of isoorientin regulating neuroinflammation after subarachnoid hemorrhage through AKT/GSK3β. [Abstract]

2026 Apr 1:174:116299. PMID: 41671619

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ahmed MH, Ghatge MS, Safo MK. Hemoglobin: Structure, Function and Allostery. Subcell Biochem. 2020;94:345-382. [Content Brief]

[2]. Ciaccio C, et al. Role of hemoglobin structural-functional relationships in oxygen transport. Mol Aspects Med. 2022 Apr;84:101022. [Content Brief]

[3]. Otterbein L, et al. Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1. Am J Respir Cell Mol Biol. 1995 Nov;13(5):595-601. [Content Brief]

[4]. Olsson MG, et al. Up-regulation of alpha1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell lines. Free Radic Biol Med. 2007 Mar 15;42(6):842-51. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Hemoglobin

4 Cited Publications

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Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Flow cytometry by Annexin V-APC:7-AAD staining and analysis of apoptosis rate. Hemoglobin (HB) (30 μM; 24 h) treatment increased the percentage of apoptotic cells in HT22 mouse hippocampal neuronal cells, as indicated by higher Annexin V-APC+/7-AAD-cells.
1/16

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Western blotting images and quantitative data of relative expression levels of 4-hydroxynonenal (4-HNE), BAX, BCL-2, and cleaved caspase-3 were presented. Hemoglobin (HB) (30 μM; 24 h) treatment upregulated levels of 4-hydroxynonenal (4-HNE), proapoptotic proteins Bax and cleaved caspase-3 while downregulated the antiapoptotic protein BCL-2.
1/16

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Hemoglobin (HB) (30 μM; 24 h) exposure led to marked increases in MDA, hydrogen peroxide and decreased superoxide dismutase (SOD) activity.
1/16

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Hemoglobin (HB) (30 μM; 24 h) caused the mitochondrial outer membranes to become denser, with some showing rupture, and reduced or eliminated cristae, and induced vacuolization and the occasional formation of autophagic vesicles.
1/16

Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Western blotting images and quantitative data of relative expression levels of p62, PINK1, PARKIN, and LC3II/I were presented. Hemoglobin (HB) (30 μM; 24 h) increased the LC3-II/I ratio and the levels of PINK1, p62, and Parkin, indicating impaired autophagic flux and enhanced mitophagy activity.

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ヘモグロビン

MedChemExpress（MCE）の使用を引用している文献 Hemoglobin

Heme Oxygenase (HO) アイソフォーム固有の製品をすべて表示