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United States

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製品番号: HY-153572A

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Homo-BacPROTAC7 TFA

Homo-BacPROTAC7 TFA is a PROTAC protein degrader targeting ClpC1/ClpC2 with a K_d of 0.5-2.5 nM for both targets. Homo-BacPROTAC7 (TFA) acts as a bactericidal agent, induces killing of pathogenic mycobacteria, retains activity against dormant-like mycobacterial cells with reduced intracellular ATP levels, and shows elevated antibiotic potency relative to its parent monomer. Homo-BacPROTAC7 (TFA) can be used for the research of tuberculosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₁₁H₁₅₀F₁₂N₂₂O₂₆
分子量:2436.49

保管条件:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Homo-BacPROTAC7 TFA 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PROTACs アイソフォーム固有の製品をすべて表示 :

体外実験

Homo-BacPROTAC7 TFA (100 μM; 2 h) induces degradation of ~80% of purified M. tuberculosis ClpC1_NTD substrate via the ClpC1P1P2 protease in vitro^[1].
Homo-BacPROTAC7 TFA (12.5 μM; 24 h) reduces ClpC1 levels to 34% and ClpC2 levels to 51% (relative to dCym7 treatment) in M. smegmatis ATCC 607 cells^[1].
Homo-BacPROTAC7 TFA (100-0.048 μM; 5 days) exhibits potent antibacterial activity against M. tuberculosis H37Rv wild-type cells with an MIC₅₀ of 0.26 μM (150-fold more potent than dCymM) and against ΔclpC2 mutant cells with an MIC₅₀ of 0.18 μM after 5 days of treatment^[1].
Homo-BacPROTAC7 TFA(7.8 μM; 48 h) induces a 5-fold reduction in ClpC1 levels and significant reduction in ClpC2 levels in M. tuberculosis H37Rv wild-type cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

性状 Solid
分子量 2436.49
分子式 C₁₁₁H₁₅₀F₁₂N₂₂O₂₆
Color White to off-white
SMILES

O=C(N[C@H](C(N(C)[C@H](C(N[C@@H](CC1=CN(CCCCCN2N=NC(C[C@H](NC([C@@H](N(C)C([C@H](C(C)C)NC([C@H]([C@@H](C3=CC=CC=C3)OC)NC([C@H](C)NC([C@@H](N4C)C[C@@H](C)CO)=O)=O)=O)=O)CC(C)C)=O)C(N[C@@H](CC5=CN(C)C6=C5C=CC=C6)C4=O)=O)=C2)N=N1)C(N[C@@H](CC7=CN(C)C8=C7C=CC=C8)C9=O)=O)=O)CC(C)C)=O)C(C)C)[C@@H](NC([C@H](C)NC([C@H](C[C@H](CO)C)N9C)=O)=O)[C@H](OC)C%10=CC=CC=C%10.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hoi DM, et al. Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell. 2023;186(10):2176-2192.e22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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