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製品番号: HY-116488

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IND8

IND8 is a α7 nAChR activator and cognitive enhancer. IND8 mediates cognitive enhancement by activating α7 nAChR . IND8 improves spatial working memory, episodic short-term memory and spatial long-term memory in amnesic mice induced by Scopolamine (HY-N0296). IND8 improves memory function in mice with delayed natural memory decline. IND8 can be used in research related to Alzheimer's disease.

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CAS 番号: 1778682-59-9
分子式: C₁₇H₁₉N₅
分子量:293.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

IND8 構造式

CAS 番号: 1778682-59-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

IND8 potently binds to and activates α7-nAChRs in cells expressing LGIC receptors, with a K_d of 0.12 μM and an EC₅₀ of 0.03 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

IND8 (5-50 μmol/kg; i.p.; single administration) rescues scopolamine (HY-N0296)-induced cognitive impairment in male ICR mice, and significantly improves their spatial working memory, episodic short-term memory and spatial reference memory^[1].
IND8 (10-25 μmol/kg; intraperitoneal injection; single administration) improves cognitive function in mice with delayed-induced natural memory decline^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male, 6-weeks of age, scopolamine-induced amnesia)^[1]
Dosage:

5 μmol/kg (1.5 mg/kg); 10 μmol/kg (2.9 mg/kg); 25 μmol/kg (7.3 mg/kg); 50 μmol/kg (14.7 mg/kg)
Administration:

i.p.; single dose
Result:

Significantly reversed scopolamine-induced cognitive deficit, with percentage of unfamiliar arm exploration significantly higher than the scopolamine-treated group.
Increased discrimination index (DI) at 10 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group, and exploration time of the novel object was significantly longer than the familiar object.
Increased time spent in the target quadrant at 25 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group.

化学情報

CAS 番号 1778682-59-9
分子量 293.37
分子式 C₁₇H₁₉N₅
SMILES

N1(C2CN3CCC2CC3)N=NC(C4=CC5=C(NC=C5)C=C4)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Arunrungvichian K, et al. Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors. ACS Chem Neurosci. 2015;6(8):1331-1340. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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