iNOs-IN-1
Based on 1 publication(s) in Google Scholar
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects.
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- 純度 : 98.07%
- 分子式: C25H28N4O5
- 分子量:464.51
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 iNOs-IN-1
More
生物活性
製品説明
IC50 & Target
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iNOS |
IL-6 |
体外実験
iNOs-IN-1 (YPW) (12.5, 25 and 50 µM; 2 hours) can significantly reduce NO production in LPS-treated RAW 264.7 cells[1].
iNOs-IN-1 (12.5, 25 and 50 µM; 2 hours) inhibits IL-6 production and iNOS protein expression in LPS-treated RAW 264.7 mouse macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 mouse macrophages[1]
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Concentration:12.5, 25 and 50 µM
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Incubation Time:2 hours
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Result:Had a significant inhibitory effect on LPS-induced iNOS expression at 50 μM (p＜0.01).
化学情報
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性状 Solid
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分子量 464.51
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分子式 C25H28N4O5
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Color White to off-white
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SMILES
N[C@@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=C(C=C4)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Hazard Mater
1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, disrupts intestinal barrier function via the IRX3/NOS2 axis in rat small intestine. [Abstract]2024 Jan 5:461:132597. PMID: 37804762
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (107.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (107.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.1528 mL | 10.7640 mL | 21.5281 mL | 53.8202 mL |
| 5 mM | 0.4306 mL | 2.1528 mL | 4.3056 mL | 10.7640 mL | |
| 10 mM | 0.2153 mL | 1.0764 mL | 2.1528 mL | 5.3820 mL | |
| 15 mM | 0.1435 mL | 0.7176 mL | 1.4352 mL | 3.5880 mL | |
| 20 mM | 0.1076 mL | 0.5382 mL | 1.0764 mL | 2.6910 mL | |
| 25 mM | 0.0861 mL | 0.4306 mL | 0.8611 mL | 2.1528 mL | |
| 30 mM | 0.0718 mL | 0.3588 mL | 0.7176 mL | 1.7940 mL | |
| 40 mM | 0.0538 mL | 0.2691 mL | 0.5382 mL | 1.3455 mL | |
| 50 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0764 mL | |
| 60 mM | 0.0359 mL | 0.1794 mL | 0.3588 mL | 0.8970 mL | |
| 80 mM | 0.0269 mL | 0.1346 mL | 0.2691 mL | 0.6728 mL | |
| 100 mM | 0.0215 mL | 0.1076 mL | 0.2153 mL | 0.5382 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
iNOs-IN-1 関連分類
HY-145846 関連分類
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