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United States

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製品番号: HY-124454

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JCC76

JCC76 is the derivative of Nimesulide (HY-B0363). JCC76 inhibits the proliferation of Her2 positive breast cancer cell SKBR-3 with IC₅₀ of 3.43 μM.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1021926-22-6
分子式: C₂₄H₃₂N₂O₄S
分子量:444.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

JCC76 構造式

CAS 番号: 1021926-22-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

JCC76 is the derivative of Nimesulide (HY-B0363). JCC76 inhibits the proliferation of Her2 positive breast cancer cell SKBR-3 with IC₅₀ of 3.43 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	20 μM Compound: JCC-76	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 29352646]
MDA-MB-231	IC₅₀	20 μM Compound: JCC-76	Growth inhibition of human MDA-MB-231 cells Growth inhibition of human MDA-MB-231 cells	[PMID: 29352646]
NCI-H292	IC₅₀	22.1 μM Compound: 40	Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy	[PMID: 23306053]
NCI-H292	IC₅₀	7.99 μM Compound: 40	Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay	[PMID: 23306053]
SK-BR-3	IC₅₀	1 μM Compound: JCC-76	Growth inhibition of human SKBR3 cells Growth inhibition of human SKBR3 cells	[PMID: 29352646]
SK-BR-3	IC₅₀	1.38 μM Compound: 3, JCC76	Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay	[PMID: 22435708]
SK-BR-3	IC₅₀	1.38 μM Compound: JCC76	Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay	[PMID: 22119125]
SK-BR-3	IC₅₀	3.17 μM Compound: 49, JCC76	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay	[PMID: 23767669]
SK-BR-3	IC₅₀	3.43 μM Compound: JCC76	Antiproliferative activity against human SKBR3 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human SKBR3 cells after 48 to 72 hrs by MTT assay	[PMID: 21807508]

化学情報

CAS 番号 1021926-22-6
分子量 444.59
分子式 C₂₄H₃₂N₂O₄S
SMILES

O=C(C1CCCCC1)NC2=CC=C(N(S(=O)(C)=O)C)C(OCC3=CC(C)=CC=C3C)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhong B, et al., Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5324-7. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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