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United States

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製品番号: HY-P11614

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LCA-H10

LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₈₄H₁₁₀N₃₀O₁₃
分子量:1747.97

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LCA-H10 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

LiLNP-LH (containing LCA-H10) (0-187.8 nM siRNA; 5 h + 43 h) provided enhanced gene silencing activity in PC3-GFP cells compared to LiLNP and LiLNP-H, with an IC₅₀ of 216.9 nM^[1].
LiLNP-LH (containing LCA-H10) (0.3 μg/mL siRNA (PC3); 1.5 μg/mL siRNA (HepG2); 5-6 h) showed comparable intracellular uptake to HiLNP in HepG2 cells and similar uptake to LiLNP in PC3 cells^[1].
LiLNP-LH (containing LCA-H10) (0.9% molar ratio) achieved high siRNA encapsulation efficiency (83.7%) comparable to HiLNP despite a low ionizable lipid proportion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

LiLNP-LH (40 μg-2 mg/kg siRNA; i.v.) enhances liver accumulation 1.6-fold and reduces inflammatory cytokine induction by 15-30-fold compared to HiLNPs in healthy C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (6 weeks old, female)^[1]
Dosage:

40 μg siRNA per mouse (biodistribution); 2 mg/kg siRNA (cytokine analysis)
Administration:

i.v.
Result:

Exhibited 4.6× 10¹⁰ total flux in the liver (1.6-fold higher than HiLNPs) and 50.4 × 10² RFI/mg organ in liver homogenates. Reduced serum IL-6 levels to 144.1 pg/mL (30.6-fold lower than HiLNPs), TNF levels by 29.9-fold, and IL-1β levels by 14.5-fold compared to HiLNPs.

Related Protocols :

化学情報

分子量 1747.97
分子式 C₈₄H₁₁₀N₃₀O₁₃
配列

LCA-His-His-His-His-His-His-His-His-His-His
シーケンスの短縮

LCA-HHHHHHHHHH
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (262 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lee JH, et al. Bile Acid-Histidine Decapeptide Conjugates as Promising Additives in Lipid Nanoparticle Formulation for siRNA Delivery. Bioconjug Chem. 2025;36(10):2197-2209. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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