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製品番号: HY-P1424

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Lei-Dab7

Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels.

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CAS 番号: 1061556-49-7
分子式: C₁₄₁H₂₃₆N₄₆O₃₉S₆
分子量:3392.06

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lei-Dab7 構造式

CAS 番号: 1061556-49-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels^[1]^[2].

体内実験

Intracerebroventricular (9-5 ng) injections of Lei-Dab7 decreases locomotor activity, food intake and body weight in rats deprived of food. A dose of 3 ng Lei-Dab7 has no effect on these types of behavior^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1061556-49-7
分子量 3392.06
分子式 C₁₄₁H₂₃₆N₄₆O₃₉S₆
配列

Ala-Phe-Cys-Asn-Leu-Arg-{Dab}-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)
シーケンスの短縮

AFCNLR-{Dab}-CQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (261 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. V G Shakkottai, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. [Content Brief]

[2]. Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11. [Content Brief]

[3]. Bedel Mpari, et al. Small-conductance Ca(2+)-activated K(+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers. Eur J Pharmacol. 2008 Jul 28;589(1-3):140-8. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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