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United States

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製品番号: HY-189090

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LEX-K02

LEX-K02 is a broad-spectrum and potent thiazole amide antifungal agent with an EC₅₀ of 0.140 μM. LEX-K02 inhibits fungal growth by disrupting the fungal cell membrane to cause leakage of intracellular substances and targeting the map00510 pathway to interfere with N-glycan biosynthesis. LEX-K02 can be used in studies related to Gaeumannomyces graminis infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3106140-37-5
分子式: C₂₈H₂₂F₄N₂O₃S
分子量:542.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEX-K02 構造式

CAS 番号: 3106140-37-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Fungal InfectionOthers

Fungal Infection

LEX-K02 (0.05-100 μM; 24 h-7 days) potently inhibits mycelial growth of Gaeumannomyces graminis with an EC₅₀ of 0.140 μM. It disrupts cell membrane integrity, increases cell membrane permeability, causes leakage of cytoplasmic contents, alters gene expression and metabolite levels in Gaeumannomyces graminis, and significantly impairs the N-glycan biosynthesis pathway^[1].

Others

LEX-K02 (6.25-100 μM) is safe for wheat; it exerts no adverse effects on seed germination or seedling growth at concentrations up to 100 μM, and exhibits a weak growth-promoting effect on roots and shoots^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 3106140-37-5
分子量 542.54
分子式 C₂₈H₂₂F₄N₂O₃S
SMILES

O=C(C1=CSC(C2=CC(F)=C(C=C2)F)=N1)N[C@@H](C)C(O[C@@H](C)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kong W, et al. Scaffold Hopping of Florylpicoxamid for Structurally and Biologically Distinct Antifungal Leads. Journal of agricultural and food chemistry. 2026 Aug 12;74(31):24149-24160.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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