LEX-K02
LEX-K02 is a broad-spectrum and potent thiazole amide antifungal agent with an EC50 of 0.140 μM. LEX-K02 inhibits fungal growth by disrupting the fungal cell membrane to cause leakage of intracellular substances and targeting the map00510 pathway to interfere with N-glycan biosynthesis. LEX-K02 can be used in studies related to Gaeumannomyces graminis infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3106140-37-5
- 分子式: C28H22F4N2O3S
- 分子量:542.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
LEX-K02 (0.05-100 μM; 24 h-7 days) potently inhibits mycelial growth of Gaeumannomyces graminis with an EC50 of 0.140 μM. It disrupts cell membrane integrity, increases cell membrane permeability, causes leakage of cytoplasmic contents, alters gene expression and metabolite levels in Gaeumannomyces graminis, and significantly impairs the N-glycan biosynthesis pathway[1].
LEX-K02 (6.25-100 μM) is safe for wheat; it exerts no adverse effects on seed germination or seedling growth at concentrations up to 100 μM, and exhibits a weak growth-promoting effect on roots and shoots[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3106140-37-5
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分子量 542.54
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分子式 C28H22F4N2O3S
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SMILES
O=C(C1=CSC(C2=CC(F)=C(C=C2)F)=N1)N[C@@H](C)C(O[C@@H](C)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LEX-K02 関連分類
HY-189090 関連分類
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