LP23
LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 3008239-25-3
- 分子式: C27H27N3O5S
- 分子量:505.59
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cancer Compound Library
HY-L025
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Small Molecule Immuno-Oncology Compound Library
HY-L031
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Lung Cancer Compound Library
HY-L075
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Liver Cancer Compound Library
HY-L101
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Anti-Colorectal Cancer Compound Library
HY-L103
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Protein-protein Interaction Inhibitor Library
HY-L109
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Anti-Hematopathy Compound Library
HY-L171
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Anti-Ovarian Cancer Compound Library
HY-L173
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Gastric Cancer Compound Library
HY-L184
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Anti-Brain Cancer Compound Library
HY-L188
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
IC50: 16.7 nM (PD-L1)[1]
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
8.9 μM
Compound: LP23
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Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
| B16-F10 | IC50 |
>10 μM
Compound: LP23
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Antitumor activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
| HepG2 | IC50 |
4.32 μM
Compound: LP23
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Antitumor immunity against IFNgamma-stimulated human HepG2 cells expressing human PD-L1 co-cultured with PHA-stimulated human Jurkat T cells expressing human PD-1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antitumor immunity against IFNgamma-stimulated human HepG2 cells expressing human PD-L1 co-cultured with PHA-stimulated human Jurkat T cells expressing human PD-1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
| MCF7 | IC50 |
7.9 μM
Compound: LP23
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Antitumor activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
化学情報
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CAS 番号 3008239-25-3
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性状 Solid
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分子量 505.59
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分子式 C27H27N3O5S
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Color White to off-white
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SMILES
O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 106 mg/mL (209.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
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- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9779 mL | 9.8894 mL | 19.7789 mL | 49.4472 mL |
| 5 mM | 0.3956 mL | 1.9779 mL | 3.9558 mL | 9.8894 mL | |
| 10 mM | 0.1978 mL | 0.9889 mL | 1.9779 mL | 4.9447 mL | |
| 15 mM | 0.1319 mL | 0.6593 mL | 1.3186 mL | 3.2965 mL | |
| 20 mM | 0.0989 mL | 0.4945 mL | 0.9889 mL | 2.4724 mL | |
| 25 mM | 0.0791 mL | 0.3956 mL | 0.7912 mL | 1.9779 mL | |
| 30 mM | 0.0659 mL | 0.3296 mL | 0.6593 mL | 1.6482 mL | |
| 40 mM | 0.0494 mL | 0.2472 mL | 0.4945 mL | 1.2362 mL | |
| 50 mM | 0.0396 mL | 0.1978 mL | 0.3956 mL | 0.9889 mL | |
| 60 mM | 0.0330 mL | 0.1648 mL | 0.3296 mL | 0.8241 mL | |
| 80 mM | 0.0247 mL | 0.1236 mL | 0.2472 mL | 0.6181 mL | |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1978 mL | 0.4945 mL |
LP23 関連分類
HY-156085 関連分類
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