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United States

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製品番号: HY-181764

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LZL50

LZL50 is an orally effective human caseinolytic protease P (hClpP) activator with an EC₅₀ of 0.29 μM. LZL50 activates hClpP, a serine protease that mediates mitochondrial quality control by degrading damaged or misfolded mitochondrial proteins. LZL50 exhibits antitumor activity in a breast cancer xenograft mouse model. LZL50 can be used in research related to breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₁H₃₃F₄N₃O₂
分子量:555.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

LZL50 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

体外実験

LZL50 (5 nM-30 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC₅₀ of 0.30 ± 0.04 μM after 72 h of treatment^[1].
LZL50 (1.0 μM; up to 120 min) has moderate metabolic stability in human liver microsomes, with a CL_int of 46.2 mL/min/kg and a T_1/2 of 39 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-t	AUC_0-∞	T_1/2
Rat^[1]	15 mg/kg	p.o.	1939.24 ng/mL	1.12 h	18403.92 ng·h/mL	19010.67 ng·h/mL	4.37 h

体内実験

LZL50 (5-20 mg/kg; p.o.; daily; 15 days) demonstrates potent dose-dependent in vivo antitumor activity in MDA-MB-231 xenografted mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude (female, 5 weeks old)^[1]
Dosage:

5 mg/kg; 10 mg/kg; 20 mg/kg
Administration:

p.o.; daily; 15 days
Result:

Nearly completely suppressed tumor growth at 20 mg/kg.
Showed no significant body weight loss in any treatment group during the 15-day treatment period.

化学情報

分子量 555.61
分子式 C₃₁H₃₃F₄N₃O₂
SMILES

O=C1N([C@H](CC2=CC=C(C=C21)CC3=CC=C(C=C3)F)COCCN4CCNCC4)CC5=CC=C(C=C5)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li Z, et al. Discovery of Activators of Human Caseinolytic Protease P with a Benzolactam Scaffold. J Med Chem. 2026;69(5):6014-6037. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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