MG-H1
MG-H1 is a RAGE ligand, advanced glycation end product cross-link, and pathogenic mediator with relevance to diabetic vasculopathy. MG-H1 binds to RAGE and competes with CM1 for RAGE binding on endothelial cells. MG-H1 is implicated in diabetic vasculopathy pathogenesis. MG-H1 can be used for the research of diabetic vasculopathy.
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- CAS 番号: 149204-50-2
- 分子式: C9H16N4O3
- 分子量:228.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MG-H1 (10-11-10-5 M; 60 min) binds to RAGE on intact human umbilical vein endothelial cells (HUVEC) with a Kd of 4.12 nM, a Bmax of 18.72 fmol/mg protein, and an IC50 of 1.699 × 10-8 M, achieving saturated binding within 60 min of incubation at 37 °C[1].
MG-H1 (10-10-10-9 M; 60 min) competes with CM1 for binding to RAGE on intact human umbilical vein endothelial cells (HUVEC), as pre-incubation with 10-10 M MG-H1 yields a CM1 IC50 of 1.37 × 10-9 M, while pre-incubation with 10-9 M MG-H1 increases the CM1 IC50 to 4.56 × 10-8 M[1].
MG-H1 (10-11-10-5 M; 60 min pre-incubation, 60 min co-incubation) dose-dependently displaces CM1 from RAGE binding sites on intact human umbilical vein endothelial cells (HUVEC), with increasing MG-H1 concentrations correlating with reduced CM1 binding and increased MG-H1 binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 149204-50-2
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分子量 228.25
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分子式 C9H16N4O3
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SMILES
OC([C@@H](N)CCCNC(NC1C)=NC1=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Feng L, et al. Competitive binding between 4,4'-diphenylmethane-bis(methyl) carbamate and RAGE ligand MG-H1 on human umbilical vein endothelial cell by cell membrane chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan 15;881-882:55-62. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MG-H1 関連分類
HY-156049 関連分類
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