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United States

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製品番号: HY-130451

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Misakimycin

Misakimycin is a naphthoquinone compound. Misakimycin exhibits cytotoxicity against human melanoma, breast cancer and ovarian cancer cells. Misakimycin can be found in strains of the genus Pyrenochaetopsis (strain MSX63693). Misakimycin can be used in research related to melanoma, breast cancer and ovarian cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 91776-49-7
分子式: C₁₃H₁₂O₅
分子量:248.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Misakimycin 構造式

CAS 番号: 91776-49-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	15 μM Compound: 6	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]
MDA-MB-435	IC₅₀	3.2 μM Compound: 6	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]
OVCAR-3	IC₅₀	9.6 μM Compound: 6	Cytotoxicity against human OVCAR-3 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human OVCAR-3 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]

体外実験

Misakimycin (72 h) inhibits the growth of human melanoma MDA-MB-435 cells, human breast cancer MDA-MB-231 cells, and human ovarian cancer OVCAR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDA-MB-435, MDA-MB-231, OVCAR3
Concentration:

/
Incubation Time:

72 h
Result:

Had an IC₅₀ of 3.2 μM for MDA-MB-435 cells, 15 μM for MDA-MB-231 cells and 9.6 μM for OVCAR3 cells.

Related Protocols :

化学情報

CAS 番号 91776-49-7
分子量 248.23
分子式 C₁₃H₁₂O₅
SMILES

O=C1C(OC)=CC(C2=C1C=C(OC)C(C)=C2O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Flores-Bocanegra L, et al. Cytotoxic Naphthoquinone Analogues, Including Heterodimers, and Their Structure Elucidation Using LR-HSQMBC NMR Experiments. J Nat Prod. 2021;84(3):771-778. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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