MSN8C
MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1314798-31-6
- 分子式: C13H10O3
- 分子量:214.22
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
More
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CNE-2 | IC50 |
2.05 μM
Compound: 7
|
Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
|
[PMID: 21600681] |
MSN8C prevents supercoiled DNA from entering the catalytic cycle to avoid capture by Topo II poisons and reduces fragmented DNA generation[1].
MSN8C (1-10 μM, 24 h) induces HL-60 cancer cell apoptosis via increases caspases-3 expression in a dose-dependent manner.[1].
MSN8C (1, 5, 10, 20 μM, 12 h) increases caspase-8 and caspase-9 activity in HL-60 cells[1].
MSN8C (48 h) inhibits human 11 tumor cell lines from various origins with an average IC50 value of 2.6 µM[1].
MSN8C has strong antiproliferative effects on the human breast cancer adriamycin (HY-15142)-resistant cell line MCF-7/Adr and mitoxantrone (HY-13502)-resistant cell line HL-60/MX2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HL-60 cells
-
Concentration:10 μM
-
Incubation Time:1 h
-
Result:Reduced γ-H2AX expression levels.Weakened the production of γ-H2AX by VP-16.
-
Cell Line:HL-60 cells
-
Concentration:1, 5, 10, 20 μM
-
Incubation Time:1, 5, 10, 20 μM
-
Result:Induced caspases-3 express in a dose-dependent manner.
-
Cell Line:HL-60 cells
-
Concentration:5, 10 μM
-
Incubation Time:12 h
-
Result:Promoted caspase-8 and caspase-9 activity in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:A549 tumor xenograft model, female BALB/c nude mice[1]
-
Dosage:10 mg/kg
-
Administration:Intraperitoneal injection (i.p.), two-day intervals for 2 weeks
-
Result:Inhibits tumor with the tumor weight inhibition (TWI) value of 74.2%.
化学情報
-
CAS 番号 1314798-31-6
-
分子量 214.22
-
分子式 C13H10O3
-
SMILES
CC(CO1)C2=C(C1=CC(C3=O)=O)C3=CC=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MSN8C 関連分類
HY-149410 関連分類
Powered by Bioz