N-Acetyllactosamine
Based on 1 Customer Validation
N-Acetyllactosamine (N-Acetyl-D-lactosamine), a nitrogen-containing disaccharide, is a galectin-3 inhibitor, which is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.83%
- CAS 番号: 32181-59-2
- 分子式: C14H25NO11
- 分子量:383.35
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-A0132
N-Acetyl-D-glucosamineEndogenous Metabolite -
HY-130778
N,N'-DiacetylchitobioseChitin Hydrolysate -
HY-126854R
N-Acetyllactosamine (Standard)Nitrogen Disaccharide -
HY-101461
Methyl-β-cyclodextrinCholesterol-removing Agent -
HY-N1132
D-(+)-TrehaloseDisaccharide -
HY-B1779
SucroseDisaccharide -
HY-N1938
D(+)-Raffinose pentahydrateBiofilm-inhibitory Agent -
HY-CP001
D-Trehalose, Carrier ProteinCarrier Protein -
HY-N1132A
D-(+)-Trehalose dihydrateEndogenous Metabolite -
HY-N0299
Stachyose hydrateEndogenous Metabolite -
HY-W011183
4-Nitrophenyl-N-acetyl-β-D-glucosaminideNAGase Substrate -
HY-N2325
D-(+)-CellobioseEndogenous Metabolite
生物活性
製品説明
IC50 & Target
|
Human Endogenous Metabolite |
Galectin-3 |
体外実験
N-Acetyllactosamine (0-10 mM, 2 h 10 min) inhibits the binding of type A progenitor toxin to intestine-407 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Cirrhotic rats[4]
-
Dosage:5 mg/kg
-
Administration:sham operation, every other day at week 4
-
Result:Significantly decreased galectin-3 expression and BNP levels in left ventricles from BDL rats and restored systolic contractility in cirrhotic cardiomyocytes.
化学情報
-
CAS 番号 32181-59-2
-
性状 Solid
-
分子量 383.35
-
分子式 C14H25NO11
-
Color White to off-white
-
SMILES
O=C[C@H](NC(C)=O)[C@H]([C@@H]([C@@H](CO)O)O[C@H]1[C@@H]([C@H]([C@H]([C@@H](CO)O1)O)O)O)O
-
別名
N-Acetyl-D-lactosamine
-
Structure Classification
-
Initial Source
Escherichia coli strains and Corynebacterium ammoniagenes
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
H2O : 100 mg/mL (260.86 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (277 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Endo T, Koizumi S, Tabata K, Kakita S, Ozaki A. Large-scale production of N-acetyllactosamine through bacterial coupling. Carbohydr Res. 1999 Mar 31;316(1-4):179-83. [Content Brief]
[3]. Kojima S, et al. Clostridium botulinum type A progenitor toxin binds to Intestine-407 cells via N-acetyllactosamine moiety. Biochem Biophys Res Commun. 2005 Jun 3;331(2):571-6. [Content Brief]
[4]. Yoon KT, et al. Galectin-3 inhibits cardiac contractility via a tumor necrosis factor alpha-dependent mechanism in cirrhotic rats. Clin Mol Hepatol. 2022 Apr;28(2):232-241. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6086 mL | 13.0429 mL | 26.0858 mL | 65.2146 mL |
| 5 mM | 0.5217 mL | 2.6086 mL | 5.2172 mL | 13.0429 mL | |
| 10 mM | 0.2609 mL | 1.3043 mL | 2.6086 mL | 6.5215 mL | |
| 15 mM | 0.1739 mL | 0.8695 mL | 1.7391 mL | 4.3476 mL | |
| 20 mM | 0.1304 mL | 0.6521 mL | 1.3043 mL | 3.2607 mL | |
| 25 mM | 0.1043 mL | 0.5217 mL | 1.0434 mL | 2.6086 mL | |
| 30 mM | 0.0870 mL | 0.4348 mL | 0.8695 mL | 2.1738 mL | |
| 40 mM | 0.0652 mL | 0.3261 mL | 0.6521 mL | 1.6304 mL | |
| 50 mM | 0.0522 mL | 0.2609 mL | 0.5217 mL | 1.3043 mL | |
| 60 mM | 0.0435 mL | 0.2174 mL | 0.4348 mL | 1.0869 mL | |
| 80 mM | 0.0326 mL | 0.1630 mL | 0.3261 mL | 0.8152 mL | |
| 100 mM | 0.0261 mL | 0.1304 mL | 0.2609 mL | 0.6521 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Acetyllactosamine 関連分類
HY-126854 関連分類
Powered by Bioz