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製品番号: HY-18223

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NITD-203

NITD-203 is a RdRp domain inhibitor. NITD 203 induces inhibition of the four DENV serotypes, as well as of YFV and WNV.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1207518-71-5
分子式: C₂₂H₂₇N₅O₇
分子量:473.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NITD-203 構造式

CAS 番号: 1207518-71-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NITD-203 is a RdRp domain inhibitor. NITD 203 induces inhibition of the four DENV serotypes, as well as of YFV and WNV^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	0.54 μM Compound: NITD203	Antiviral activity against Dengue virus 1 MY10245 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 1 MY10245 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.54 μM Compound: NITD203	Antiviral activity against Dengue virus 3 MY22366 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 3 MY22366 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.57 μM Compound: NITD203	Antiviral activity against Dengue virus 2 MY10340 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 2 MY10340 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.69 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 2 NGC infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.71 μM Compound: NITD203	Antiviral activity against Dengue virus 4 MY22713 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 4 MY22713 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.76 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 2 mg/ml alpha-1-acid glycoprotein Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 2 mg/ml alpha-1-acid glycoprotein	[PMID: 20516277]
A549	EC₅₀	0.79 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin	[PMID: 20516277]
A549	EC₅₀	0.85 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin and 2 mg/ml alpha-1-acid glycoprotein Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin and 2 mg/ml alpha-1-acid glycoprotein	[PMID: 20516277]
PBMC	EC₅₀	0.1 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human PBMC cells by plaque assay Antiviral activity against Dengue virus 2 NGC infected in human PBMC cells by plaque assay	[PMID: 20516277]

化学情報

CAS 番号 1207518-71-5
分子量 473.48
分子式 C₂₂H₂₇N₅O₇
SMILES

O[C@]1(C#C)[C@H](OC(C(C)C)=O)[C@@H](COC(C(C)C)=O)O[C@H]1N2C=C(C(N)=O)C3=C2N=CN=C3N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. García LL, et al. Inhibitors compounds of the flavivirus replication process. Virol J. 2017 May 15;14(1):95. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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