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製品番号: HY-130303

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Nutlin-2

Nutlin-2 is an inhibitor of the interaction between p53 and MDM2, with an IC₅₀ of 0.14 μM. Nutlin-2 disrupts the p53-MDM2 protein-protein interaction by occupying the hydrophobic pocket on MDM2 that normally binds to the hydrophobic residues of p53.

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CAS 番号: 548472-76-0
分子式: C₃₁H₃₄Br₂N₄O₄
分子量:686.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nutlin-2 構造式

CAS 番号: 548472-76-0

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Nutlin-2 inhibits the p53-MDM2 protein-protein interaction in a cell-free assay with an IC₅₀ of 0.14 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 548472-76-0
分子量 686.43
分子式 C₃₁H₃₄Br₂N₄O₄
SMILES

O=C(N1[C@@H](C2=CC=C(Br)C=C2)[C@@H](C3=CC=C(Br)C=C3)N=C1C4=CC=C(OC)C=C4OCC)N5CCN(CCO)CC5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Miyazaki M, et al. Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships. Bioorg Med Chem Lett. 2012;22(20):6338-6342. [Content Brief]

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モル濃度計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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