ONO-2921
ONO-2921 is an orally active and selective N-type calcium channel blocker. ONO-2921 functionally blocks N-type calcium channels. ONO-2921 reduces paw withdrawal responses during persistent nociception and hyperalgesia to heat in neuropathic pain models. ONO-2921 can be used for research on neuropathic pain and nociceptive pain.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 253306-39-7
- 分子式: C31H48N4O4S2
- 分子量:604.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | IC50 |
0.33 μM
Compound: 9
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In vitro inhibition of N-type calcium channel influx in IMR-32 human neuroblastoma cells
In vitro inhibition of N-type calcium channel influx in IMR-32 human neuroblastoma cells
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[PMID: 12161113] |
ONO-2921 (compound 9) inhibits N-type calcium channels in IMR-32 human neuroblastoma cells with an IC50 of 0.33 μM, and exhibits 15-fold selectivity over L-type calcium channels in AtT-20 mouse pituitary tumor-derived cells[1].
ONO-2921 (3 μM) inhibits 76% of N-type calcium channel currents in IMR-32 human neuroblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ONO-2921 (30 mg/kg; p.o.; single administration) produces significant analgesic effects in the rat CCI neuropathic pain model[1].
ONO-2921 (100 mg/kg; p.o.; single administration) causes no significant cardiovascular or neurological side effects in healthy brown rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats treated formalin[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Significantly inhibited paw flinching during the persistent nociceptive phase .
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Animal Model:Rats with chronic constriction injury (CCI)[1]
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Dosage:30 mg/kg
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Administration:p.o.; single dose
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Result:Exhibited significant antinociceptive effects on thermal hyperalgesia induced by sciatic nerve CCI.
化学情報
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CAS 番号 253306-39-7
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分子量 604.87
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分子式 C31H48N4O4S2
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SMILES
O=C(NC1CCN(CC1)CC2=CC=CC=C2)[C@H](CSCC3CCCCC3)NC([C@H]4N(CSC4)C(OC(C)(C)C)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ONO-2921 関連分類
HY-182351 関連分類
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- ONO-2921
- 253306-39-7
- ONO2921
- ONO 2921
- Calcium Channel
- rats
- L-type calcium channels
- rat CCI neuropathic pain model
- thermal hyperalgesia
- neuropathic pain
- IMR-32 human neuroblastoma cells
- nociceptive pain
- AtT-20 mouse pituitary tumor-derived cells
- N-type calcium channels
- rat formalin-induced pain model
- Inhibitor
- inhibitor
- inhibit