Pac-525

Pac-525 (0.98-500 µg/mL; 24 h) potently inhibits the growth of planktonic *Escherichia coli* KV203, with an MIC of 62.5 µg/mL and an MIC₅₀ of 41.0 µg/mL^[1].
Pac-525 (2-4 μM; 18 h) exhibits antibacterial activity against E. coli (ATCC 25922, ATCC 10536), Pseudomonas aeruginosa (ATCC 27853), and S. aureus (ATCC 29213, ATCC 33591)^[2].
Pac-525 (1.95-500 µg/mL; 24 h) exhibits cytotoxicity against RAW 264.7 cells, with an IC₇₀ of 330.88 µg/mL, and reduces cell viability to 40% at a concentration of 500 µg/mL^[1].
Pac-525 (350 μM; 1 h) exhibits extremely low hemolytic activity against human red blood cells, and can induce 50% cell lysis^[2].
Pac-525 (~1 μM, 25°C) exhibits strong membrane-disrupting activity and induces approximately 100% calcein release from large unilamellar vesicles (LUVs) composed of POPG, POPC/POPG (3:1), and POPC^[2].
Pac-525 (250 µg/mL; 4 h) reduces the intracellular load of *E. coli* KV203 by 23.6% in infected RAW 264.7 cells, but exhibits very limited penetration ability into RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.