PAK4-IN-3
PAK4-IN-3(compound 27e) is aPAK4inhibitor, with theIC50of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC50value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1.
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- 分子式: C21H22ClN7O
- 分子量:423.90
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
10 nM(PAK4)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.61 μM
Compound: 27e
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 37864885] |
| HEK-293T | IC50 |
>10 μM
Compound: 27e
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Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 37864885] |
化学情報
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分子量 423.90
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分子式 C21H22ClN7O
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SMILES
N[C@H](C(C)C)CNC(C1=NC2=CC=C(C=C2C(NC3=NNC4=C3C=CC=C4)=N1)Cl)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PAK4-IN-3 関連分類
HY-156453 関連分類
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