Paraherquamide E
Paraherquamide E is a paraherquamide alkaloid and 14C-deshydroxy paraherquamide analog found in Aspergillus aculeatus GC-147‑5 and Penicillium charlesii, with insecticidal and reproductive toxicant activity, high selectivity, and negligible toxicity to nontarget ladybugs.Paraherquamide E disrupts fatty acid synthesis, inhibits vitellogenin production, alters metabolic homeostasis, induces ovarian abnormalities, and causes Asian citrus psyllid mortality, while remaining inactive against Asian citrus psyllid cholinergic systems.
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- CAS 番号: 125600-53-5
- 分子式: C28H35N3O4
- 分子量:477.60
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Paraherquamide E (50-2000 μg/mL; spray; single administration) shows extremely low toxicity to non-target ladybugs, with LD50 values both >2000 μg/mL at 48 h and 60 h post-treatment[1].
Paraherquamide E (11.17 μg/mL; 7 days) causes ovarian abnormalities in adult female Asian citrus psyllids when applied to fifth-instar nymphs[1].
Paraherquamide E (50-2000 μg/mL; 48-60 h) exhibits negligible toxicity to adult *Harmonia axyridis*, with LD50 values >2000 μg/mL at both 48 h and 60 h[1].
Paraherquamide E (50-2000 μg/mL; spray; single administration) shows extremely low toxicity to non-target ladybugs, with LD50 values >2000 μg/mL at both 48 h and 60 h post-treatment[1].
Treatment with Paraherquamide E (11.17 μg/mL; 24 h) reduces the content of free fatty acids in adult Asian citrus psyllids[1].
Paraherquamide E (11.17 μg/mL; 6-24 h) transiently inhibits the expression of vitellogenin and fatty acid synthesis genes in adult Asian citrus psyllids, and exerts biphasic regulatory effects on the expression of PPIF and H2B genes within 6-24 h[1].
Paraherquamide E (11.17 μg/mL; 12 h) alters gene expression in adult Asian citrus psyllids, and exerts significant effects on nutrient storage activity, lipid transport activity, and the fatty acid biosynthesis pathway[1].
Paraherquamide E (4.84-19.93 μg/mL; 24 h) disrupts metabolic homeostasis in adult Diaphorina citri by altering the activities of alanine aminotransferase, glutamate decarboxylase, and Ca2+/Mg2+-ATPase, as well as the contents of glutamate and γ-aminobutyric acid, but exerts no effect on the cholinergic system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 125600-53-5
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性状 Solid
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分子量 477.60
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分子式 C28H35N3O4
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Color White to off-white
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SMILES
CC1([C@@]2([H])[C@@](CN3[C@@](C4=O)([C@H](CC3)C)C2)(N4C)C[C@]15C6=C(C7=C(OC(C)(C)C=CO7)C=C6)NC5=O)C
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Structure Classification
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Initial Source
Penicillium charlesii.
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
Methanol : 1 mg/mL (2.09 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1].
You M, et al. Discovery of Paraherquamide E as an Eco-Friendly Insecticide against Asian Citrus Psyllid from the Endophyte Aspergillus aculeatus GC-147-5 and Its Mode of Action. J Agric Food Chem. 2025 Oct 15;73(41):26101-26113.
[Content Brief]
[2]. Liesch JM, et al. Novel antinematodal and antiparasitic agents from Penicillium charlesii. II. Structure determination of paraherquamides B, C, D, E, F, and G. J Antibiot (Tokyo). 1990 Nov;43(11):1380-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 2.0938 mL | 10.4690 mL | 20.9380 mL | 52.3451 mL |
Paraherquamide E 関連分類
HY-N10220 関連分類
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