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製品番号: HY-161873

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PW507

PW507 is a potent, brain-penetrant and selective sigma 1 receptor (S1R) antagonist with a K_i of 7.5 nM for human S1R. PW507 displays a low binding affinity to S2R and hERG. PW507 can be used for the study of painful diabetic neuropathy (PDN).

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CAS 番号: 2573850-59-4
分子式: C₁₈H₂₇ClN₄
分子量:334.89

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PW507 構造式

CAS 番号: 2573850-59-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Sigma Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

PW507 binds to the orthosteric site of the human S1R crystal structure and engages in strong interactions with the receptor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

PW507 (20 mg/kg; i.p; twice daily; for 14 days) demonstrates significant efficacy in alleviating mechanical allodynia hyperalgesia^[1].
PW507’s Pharmacokinetic Properties in SD rats Studies^[1].
1.19

plasma PK	IV	PO	IP
dose (mg/kg)	1	25	10
t_max (h)	N/A	1.20	0.25
t_1/2 (h)	0.53	0.69	0.56
C_max (ng/mL)	193	296	671
AUC_0-inf (h*ng/mL)	108	692	552
CL (mL/min/kg)	155	N/A	N/A
ratio (brain/plasma, t = 0.25 h)	N/A	N/A	12
F (%)	100	28	51

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats injected Streptozotocin (HY-13753; STZ; 60 mg/kg)^[1]
Dosage:

20 mg/kg
Administration:

i.p; twice daily; for 14 days
Result:

Demonstrated significant efficacy in alleviating mechanical allodynia hyperalgesia.

化学情報

CAS 番号 2573850-59-4
分子量 334.89
分子式 C₁₈H₂₇ClN₄
SMILES

CC(C)(C)C1=CC=C(C2=NC(CN3CCCC3)=NN2C)C=C1.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Youyi Peng, et al. Preclinical Evaluation of Sigma 1 Receptor Antagonists as a Novel Treatment for Painful Diabetic Neuropathy. ACS Pharmacol. Transl. Sci. July 18, 2024.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

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体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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