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United States

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製品番号: HY-P11625

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R9-13

R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₉₄H₄₇₈N₇₈O₈₃S₉
分子量:6722.00

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

R9-13 構造式

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

R9-13 (0.9-30 nmol/kg (30 μg/kg); single dose; administered via injection) exhibits a dose-dependent and sustained pubic ligament elongation (PLE) effect in estrogen-pretreated female CD1 mice, with an ED₅₀ of 5 nmol/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD1 (female; estrogen-primed)^[1]
Dosage:

0.9, 3.0, 9, 30 nmol/kg; 1, 10, 30 nmol/kg
Administration:

single dose; measured at 168 h after treatment
Result:

Observed dose-responsive pubic ligament elongation at 24 hours post-dosing; sustained elongation effect at 168 hours post-dosing.

化学情報

分子量 6722.00
分子式 C₂₉₄H₄₇₈N₇₈O₈₃S₉
配列

Chain1:{pGln}-Cys(carbamic acid-PEG2-carbamic acid-PEG2-Lys-C18diacid)-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Ile-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys; Chain2:Ala-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser (Disulfidebridge:Chain 1 Cys10-Chain 1 Cys15,Chain 1 Cys11-Chain 2 Cys11,Chain 1 Cys24-Chain 2 Cys23
シーケンスの短縮

Chain1:{pGln}-Cys(carbamic acid-PEG2-carbamic acid-PEG2-Lys-C18diacid)-YSALANKCCHVGCIKRSLARFC; Chain2:ASWMEEVIKLCGRELVRAQIAICGMSTWS (Disulfidebridge:Chain 1 Cys10-Chain 1 Cys15,Chain 1 Cys11-Chain 2 Cys11,Chain 1 Cys24-Chain 2 Cys23
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Muppidi A, et al. Design and Synthesis of Potent, Long-Acting Lipidated Relaxin-2 Analogs. Bioconjug Chem. 2019;30(1):83-89. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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