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製品番号: HY-139008

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RC363

RC363 is a glutathione peroxidase 1 (GPx1) activator. RC363 enhances glutathione peroxidase activity and inhibits ferroptosis. RC363 can be used for the research of neurodegenerative conditions.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2584411-86-7
分子式: C₁₈H₂₄OS₂
分子量:320.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RC363 構造式

CAS 番号: 2584411-86-7

容量

価格（税別）

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

GPX1

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示 :

GPX1
GPX4

体外実験

RC363 (0.0625-3 μM; 1-48 h) inhibits glutamate-induced cytotoxicity in HT-22 cells^[1].
RC363 (3 μM; 6 h) does not significantly decrease oxidant levels in HT-22 cells^[1].
RC363 (3 μM; 24 h) significantly increases the protein level of GPx1 in HT-22 cells^[1].
RC363 (0.0625-1 μM; 24 h) inhibits RSL3 (HY-100218A)-induced ferroptosis in HT-22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-22 cells, primary cortical neurons
Concentration:

3 μM
Incubation Time:

48 h
Result:

Exhibited no cytotoxicity to HT-22 cells.
Inhibited glutamate-induced ferroptosis.

Cell Viability Assay^[1]

Cell Line:

HT-22 cells
Concentration:

0.0625 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
Incubation Time:

1 h; 2 h; 4 h; 6 h; 8 h
Result:

Exhibited fully protective at the concentration of ≥0.5 μM.
Presented significant protective effects when added simultaneously with glutamate. Gradually lost protection when the compound was added longer periods after the challenge.

Western Blot Analysis^[1]

Cell Line:

HT-22 cells
Concentration:

3 μM
Incubation Time:

24 h
Result:

Significantly increased the protein level of GPx1.

化学情報

CAS 番号 2584411-86-7
分子量 320.51
分子式 C₁₈H₂₄OS₂
SMILES

OC1=C(C(C)(C)C)C=C(SC2=CC=CS2)C=C1C(C)(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bueno DC, et al. New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells. Mol Neurobiol. 2020;57(8):3273-3290. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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RC363

High-Throughput Bioactive Compound Library

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

RC363 関連分類

HY-139008 関連分類