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製品番号: HY-123313

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S-8660

S-8660 is an orally active, selective inhibitor of dihydroorotate dehydrogenase (DHODH). As an antiproliferative prodrug and an analog of Brequinar (HY-108325), S-8660 exhibits immunosuppressive activity. Its effect on prolonging cardiac allograft survival is enhanced when used in combination with Cyclosporin A (HY-B0579). S-8660 can be used in studies of cardiac transplant rejection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 96201-52-4
分子式: C₂₃H₁₆ClNO₂
分子量:373.83

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

S-8660 構造式

CAS 番号: 96201-52-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

S-8660 selectively inhibits mitochondrial dihydroorotate dehydrogenase, disrupting de novo pyrimidine synthesis in a cell-free biochemical system^[1].
S-8660 suppresses human mixed-lymphocyte responses in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

S-8660 (5-20 mg/kg; p.o.; once daily; starting 2 days pre-transplant for up to 30 days post-transplant) prolongs cardiac allograft survival in rats in a dose-dependent fashion, with a tapered dose regimen achieving a median survival time of 32 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ACI (RT1a) donors; Lewis (RT1¹) recipients^[1]
Dosage:

5 mg/kg; 20 mg/kg
Administration:

p.o.; once daily; starting 2 days pre-transplant for up to 30 days post-transplant
Result:

Extended cardiac allograft survival in a dose-dependent manner.
Achieved a median graft survival time of 32 days with the tapered dose regimen, compared to control median survival of 7 days.

化学情報

CAS 番号 96201-52-4
分子量 373.83
分子式 C₂₃H₁₆ClNO₂
SMILES

O=C(O)C1=C(C(C2=CC=C(C=C2)C3=CC=CC=C3)=NC4=CC=CC(Cl)=C14)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Cramer DV, et al. Inhibition of the pyrimidine biosynthetic pathway with S-8660, an analogue of brequinar sodium, prolongs cardiac allograft survival in rats. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1993;12(1 Pt 1):140-6.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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