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製品番号: HY-182252

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SAR296968

SAR296968 is a Na⁺/Ca²⁺ exchanger (NCX) subtype inhibitor with an IC₅₀ value of 74 nM against hNCX1. SAR296968 inhibits both forward and reverse modes of NCX current. SAR296968 enhances cardiac contractility and stroke volume. SAR296968 exerts antiarrhythmic effects. SAR296968 is applicable to research related to heart failure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1426899-28-6
分子式: C₂₂H₂₂N₂O₄S
分子量:410.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SAR296968 構造式

CAS 番号: 1426899-28-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

SAR296968 potently inhibits hNCX1 in CHO cell lines, with an IC₅₀ value of 74 nM^[1].
SAR296968 potently inhibits both forward and reverse modes of endogenous NCX currents in guinea pig cardiomyocytes, with corresponding IC₅₀ values of 34.9 nM and 38.9 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SAR296968 (1.5 mg/kg; i.v.; over 20 minutes) (administered as SAR340835, its prodrug) increases left ventricular contractility by 49% and reduces electrically induced atrial arrhythmias by 74% in anesthetized pigs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain (pentobarbital-anesthetized)^[1]
Dosage:

1.5 mg/kg
Administration:

i.v.; over 20 minutes
Result:

Increased left ventricular contractility by 49% (dP/dtmax rose from 1423 ± 144 mm Hg/s at baseline to 2115 ± 189 mm Hg/s post-infusion).
Reduced the incidence of atrial arrhythmias by 74% (6.56 ± 1.99 events post-treatment vs.
25.50 ± 1.75 events at baseline, n=8, P<0.001).
Showed no changes in left or right atrial effective refractory period regardless of basic cycle length.

化学情報

CAS 番号 1426899-28-6
分子量 410.49
分子式 C₂₂H₂₂N₂O₄S
SMILES

CC(C=CC=C1)=C1[C@H]2OC3=CC=C(C=C3CC2)OC4=NC=C(C(NCCO)=O)S4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pelat M, et al. SAR340835, a Novel Selective Na⁺/Ca²⁺ Exchanger Inhibitor, Improves Cardiac Function and Restores Sympathovagal Balance in Heart Failure. J Pharmacol Exp Ther. 2021;377(2):293-304. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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