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United States

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製品番号: HY-181352

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SB-140

SB-140 is a selective, covalent PLpro inhibitor with an IC₅₀ of ≤2.5 nM against SARS-CoV-2 PLpro. SB-140 has antiviral activity against SARS-CoV-2, MERS-CoV and SARS-CoV-1.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₈H₃₅F₃N₄O₃
分子量:532.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SB-140 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

SB-140 is a selective, covalent PLpro inhibitor with an IC₅₀ of ≤2.5 nM against SARS-CoV-2 PLpro. SB-140 has antiviral activity against SARS-CoV-2, MERS-CoV and SARS-CoV-1^[1].

体外実験

SB-140 (15 min) potently inhibits purified SARS-CoV-2 PLpro with an IC₅₀ ≤ 2.5 nM^[1].
SB-140 (1 μM) exhibits high selectivity, with no inhibitory activity detected against 47 human DUBs and 9 cysteine proteases at a concentration of 1 μM^[1].
SB-140 (0-10 μM; 1 h) potently inhibits SARS-CoV-2 replication in A549-ACE2 cells, with an EC₅₀ of 0.3 nM and an EC₉₀ of 3 nM^[1].
SB-140 (0.01-100 μM) exhibits attenuated inhibitory activity against MERS-CoV replication in A549-ACE2 cells, with an EC₅₀ of 1.17 μM^[1].
SB-140 (0-1 μM) inhibits SARS-CoV-1 in A549-ACE2 cells, with an EC₅₀ of 14.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SB-140 (10 mg/kg; i.p.; twice daily; 5 days) reduces lung viral load by 15-fold in K18-hACE2 mice infected with SARS-CoV-2 variant β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 532.60
分子式 C₂₈H₃₅F₃N₄O₃
SMILES

CCOC1=CC2=C(C=CC=C2[C@@H](C)N3CCC([C@@H](CN)C(NCC(NCC#CC(F)(F)F)=O)=O)CC3)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sharafi M, et al. Structure-Guided Design of Potent and Selective Covalent Inhibitors Targeting the SARS-CoV-2 Papain-like Protease. J Med Chem. 2026;69(3):2197-2214. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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