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製品番号: HY-183936

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SDUY127

SDUY127 is a bivalent SHP2 inhibitor with an IC₅₀ value of 16 nM. SDUY127 binds simultaneously to the tunnel allosteric site and latch allosteric site of SHP2 at a 1:1 stoichiometric ratio, stabilizes the protein in an inactive conformation, and induces sustained inhibition of the MAPK signaling pathway. SDUY127 can be used in research related to leukemia and hepatocellular carcinoma.

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分子式: C₅₈H₆₉Cl₂N₁₃O₉S
分子量:1195.22

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SDUY127 構造式

容量

価格（税別）

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数量

Sample (0.1mg)

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(In Japan)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

p38 MAPK アイソフォーム固有の製品をすべて表示 :

ERK アイソフォーム固有の製品をすべて表示 :

体外実験

SDUY127 (1-3 μM; 48 h) inhibits MV4-11 leukemia cell proliferation by 33% at 1 μM and 79% at 3 μM after 48 h of treatment^[1].
SDUY127 (10-30 μM; 48 h) inhibits Hep3B hepatocellular carcinoma cell proliferation by 23% at 10 μM and 84% at 30 μM after 48 h of treatment^[1].
SDUY127 (3 μM; 15 min; 2 h) induces sustained suppression of ERK phosphorylation in MV4-11 cells, maintaining ~76% inhibition at 2 h post-treatment^[1].
SDUY127 (3 μM; 15 min; 2 h) induces transient suppression of ERK phosphorylation in Hep3B cells, with inhibition decreasing from ~76% at 15 min to ~48% at 2 h post-treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MV4-11 leukemia cells
Concentration:

3 μM
Incubation Time:

15 min; 2 h
Result:

Suppressed pERK levels by ~79% at 15 min.
Maintained pERK suppression at ~76% at 2 h.

Western Blot Analysis^[1]

Cell Line:

Hep3B hepatocellular carcinoma cells
Concentration:

3 μM
Incubation Time:

15 min; 2 h
Result:

Suppressed pERK levels by ~76% at 15 min.
Decreased pERK inhibition to ~48% at 2 h.

化学情報

分子量 1195.22
分子式 C₅₈H₆₉Cl₂N₁₃O₉S
SMILES

COC1=C(C=CC=C1C(N2C3=C4C=CC=C3)=NN=C2N(C4=O)CC5=CC=CC=C5Cl)OCCOCCOCCOCCN6CCN(CC6)C(CCCNC(CC(NC7=CC=CC(SC8=C(N)N=C(N9CCC(C)(CC9)N)C=N8)=C7Cl)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhu C, et al. Dual Allosteric Targeting of SHP2: Development of Bivalent Inhibitors with Enhanced Potency for Cancer Treatment. J Med Chem. 2026;69(10):11819-11843. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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参考文献

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SDUY127

p38 MAPK アイソフォーム固有の製品をすべて表示

ERK アイソフォーム固有の製品をすべて表示