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製品番号: HY-187641

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ST056083

ST056083 is a small-molecule inhibitor of the c-di-AMP synthase DisA. The apparent K_D of ST056083 binding to DisA is 21 μM. ST056083 reduces c-di-AMP production in Enterococcus faecalis ATCC 29212, and inhibits bacterial growth, biofilm formation, bacterial viability within biofilms, and the synthesis of water-insoluble extracellular polysaccharides. ST056083 is applicable to studies on bacterial c-di-AMP signaling and E. faecalis-associated infections.

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CAS 番号: 299419-24-2
分子式: C₁₀H₆Br₂N₂O₂S
分子量:378.04

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ST056083 構造式

CAS 番号: 299419-24-2

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[2]

DisA

56 μM (IC₅₀)

体外実験

OthersBacterial InfectionNucleotide Metabolism

Others

ST056083 (90 or 180 μM; 100 μM ATP; 12 μM E. faecalis DisA) blocks DisA-catalyzed c-di-AMP production^[1].
ST056083 (90 or 180 μM) significantly reduces c-di-AMP levels in cultures of E. faecalis ATCC 29212^[1].

Bacterial Infection

ST056083 inhibits bacterial growth of E. faecalis ATCC 29212^[1].

ST056083 (90 or 180 μM; 48 h; 37°C; anaerobic conditions) inhibits E. faecalis biofilm formation and disrupts biofilm structure, with the effect of 180 μM being stronger than that of 90 μM^[1].
ST056083 (90 or 180 μM; 48 h) reduces the average thickness of E. faecalis biofilms from 21.82 μm in the control group to 13.29 μm and 10.29 μm, respectively, and increases bacterial death within the biofilms; the dead/live ratios reach 1.73 and 2.79 at 90 and 180 μM, compared with 1.13 in the control group^[1].

Nucleotide Metabolism

ST056083 binds to DisA with an apparent K_D of 21 μM^[2].
ST056083 inhibits c-di-AMP synthesis catalyzed by DisA, with an IC₅₀ of 56 μM under conditions of 5 μM DisA and 50 μM ATP; when ATP is increased to 500 μM, the IC₅₀ reaches 100 μM, and ATP at a maximum concentration of 1 mM cannot abolish the binding of ST056083 to DisA, indicating that it does not compete with ATP for DisA binding^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 299419-24-2
分子量 378.04
分子式 C₁₀H₆Br₂N₂O₂S
SMILES

O=C1NC(N/C1=C\C2=C(O)C(Br)=CC(Br)=C2)=S
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Chen L, et al. Inhibition of Enterococcus faecalis Growth and Biofilm Formation by Molecule Targeting Cyclic di-AMP Synthetase Activity. Journal of endodontics. 2018 Sep;44(9):1381-1388.e2.

[2]. Zheng Y, et al. Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay. Chemical communications (Cambridge, England). 2014 Oct 04;50(76):11234-7.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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