XAT-13
XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3107904-58-2
- 分子式: C20H16O5
- 分子量:336.34
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
MRGPRX2 |
体外実験
XAT-13 (up to 100 μmol/L) shows no cytotoxicity in LAD2 cells[1].
XAT-13 (25-100 μmol/L) inhibits C48/80-induced β-hexosaminidase release from LAD2 cells in a dose-dependent manner, with an IC50 of 57.27 ± 0.13 μmol/L, and is more potent than Imperatorin (HY-N0285)[1].
XAT-13 (25-100 μmol/L) dose-dependently inhibits C48/80-induced intracellular calcium influx in MRGPRX2-HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C48/80-induced local allergy[1]
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Dosage:4, 8, 16 mg/kg
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Administration:p.o.
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Result:Attenuated the hind paws thickness.
Resulted in statistically significant differences in serum histamine levels.
化学情報
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CAS 番号 3107904-58-2
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分子量 336.34
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分子式 C20H16O5
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SMILES
O=C1OC2=C(OCCCOC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
XAT-13 関連分類
HY-181891 関連分類
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