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Cat. No.: HY-149032

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Kobusine derivative-1

Kobusine derivative-1 is a Kobusine derivative. Kobusine derivative-1 shows antiproliferative activities against cancer cells.

For research use only. We do not sell to patients.

Formula: C₃₆H₃₃F₆NO₄
Molecular Weight:657.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Kobusine derivative-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Kobusine derivative-1 is a Kobusine derivative. Kobusine derivative-1 shows antiproliferative activities against cancer cells^[1].

In Vitro

Kobusine derivative-1 (0-20 μM; 72 h) exhibits significant antiproliferative activities against five human cancer cell lines^[1].
Kobusine derivative-1 (13.5 μM; 12 or 24 h) treatment likely induces apoptosis within 12 h, decreases numbers of cells in S and G2/M phases, resulting in accumulation of sub-G1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A549, MDA-MB-231, MCF-7, KB, and KB-VIN cells
Concentration:

0-20 μM
Incubation Time:

72 hours
Result:

Inhibited A549, MDA-MB-231, MCF-7, KB, and KB-VIN cells with IC₅₀ values of 4.8, 4.5, 4.7, 4.6, and 4.8 μM, respectively.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-23 cells
Concentration:

13.5 μM
Incubation Time:

12 or 24 hours
Result:

Disrupted normal cell cycle progression after 12 h, decreased numbers of cells in S and G2/M phases, resulted in accumulation of sub-G1.

Chemical Information

Molecular Weight 657.64
Formula C₃₆H₃₃F₆NO₄
SMILES

C[C@]12[C@]3([H])[C@]4(CCC1)[C@@](N(C2)[C@H]3C5)([H])[C@@H](C[C@@H]6C7=C)[C@@]5([C@@H]7OC(C8=CC=C(C(F)(F)F)C=C8)=O)[C@@]4([H])[C@H]6OC(C9=CC=C(C(F)(F)F)C=C9)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koji Wada, et al. Discovery of C20-Diterpenoid Alkaloid Kobusine Derivatives Exhibiting Sub-G1 Inducing Activity. ACS Omega

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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