ST3GAL2 - ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Gene

Also Known as SIAT4B; ST3GALII; Gal-NAc6S; ST3GalA.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6483

About ST3GAL2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,375,977-70,439,100 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 14 paralogues. Ubiquitous expression in appendix (RPKM 6.9), spleen (RPKM 6.8) and 24 other tissues.

Summary

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of Glycosyltransferase family 29, can use the same acceptor substrates as does Sialyltransferase 4A. [provided by RefSeq, Jul 2008]

ST3GAL2 Products (1)

mRNA	Protein	Name
NM_006927.4	NP_008858.1	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	IDA IDA: Inferred from direct assay	9266697	GOA
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IDA IDA: Inferred from direct assay	8920913	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25916169	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ganglioside biosynthetic process via lactosylceramide	IDA IDA: Inferred from direct assay	8920913	GOA
involved in globoside biosynthetic process via lactosylceramide	IDA IDA: Inferred from direct assay	12716912	GOA
involved in glycolipid biosynthetic process	IDA IDA: Inferred from direct assay	9266697	GOA
involved in glycoprotein biosynthetic process	IDA IDA: Inferred from direct assay	9266697	GOA
involved in lipid glycosylation	IDA IDA: Inferred from direct assay	9266697	GOA
involved in oligosaccharide biosynthetic process	IDA IDA: Inferred from direct assay	9266697	GOA
involved in protein glycosylation	IDA IDA: Inferred from direct assay	9266697	GOA
involved in protein sialylation	IDA IDA: Inferred from direct assay	9266697	GOA
involved in sialylation	IDA IDA: Inferred from direct assay	9266697	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	25916169	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST3GAL2 Protein Structure

Glyco_transf_29

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2	Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase

Related Diseases

Diseases	Alias
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Salt And Pepper Syndrome	Salt & Pepper Syndrome Salt-And-Pepper Syndrome
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70146	ST3 β-Gal α-2,3-Sialyltransferase 2		/	Unkown
HY-RS13847	ST3GAL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ST3GAL2	VGNC	VGNC:77826
Mus musculus	ST3GAL2	MGD	MGI:99427
Rattus norvegicus	ST3GAL2	RGD	RGD:68413
Felis catus	ST3GAL2	VGNC	VGNC:65720
Bos taurus	ST3GAL2	VGNC	VGNC:35332
Canis familiaris	ST3GAL2	VGNC	VGNC:46851
Others	ST3GAL2	NCBI