CORO6 - coronin 6 Gene

Also Known as ClipinE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84940

About CORO6

This gene has 16 transcripts (splice variants), 187 orthologues and 6 paralogues. Biased expression in heart (RPKM 15.3), placenta (RPKM 14.7) and 12 other tissues.

Summary

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. [provided by Alliance of Genome Resources, Apr 2022]

CORO6 Products (10)

mRNA Protein Name
NM_001351301.3 NP_001338230.1 coronin-6 isoform 2
NM_001351302.3 NP_001338231.1 coronin-6 isoform 2
NM_001388431.1 NP_001375360.1 coronin-6 isoform 1
NM_001388433.1 NP_001375362.1 coronin-6 isoform 3
NM_001388434.1 NP_001375363.1 coronin-6 isoform 3
NM_001388435.1 NP_001375364.1 coronin-6 isoform 4
NM_001388436.1 NP_001375365.1 coronin-6 isoform 5
NM_001388437.1 NP_001375366.1 coronin-6 isoform 6
NM_001388438.1 NP_001375367.1 coronin-6 isoform 7
NM_032854.4 NP_116243.2 coronin-6 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO6 Protein Structure

DUF1899

DUF1899: Domain of unknown function (DUF1899) (4 - 68)

WD40

WD40: WD domain, G-beta repeat (78 - 109)

WD40

WD40: WD domain, G-beta repeat (122 - 160)

WD40

WD40: WD domain, G-beta repeat (174 - 203)

Trimer_CC

Trimer_CC: Trimerisation motif (257 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

coronin-6

  • clipin-E

CORO6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CORO6 Q6QEF8 BLOC1S6 Homo sapiens Q9UL45
Validated Y2H
25416956
Intra
CORO6 Q6QEF8 BLOC1S6 Homo sapiens Q9UL45
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CORO6 Proteins

Cat. No. Product Name Accession Purity
HY-P70079 Coronin-6/CORO6 Protein, Human (His) Q6QEF8-4 (M1-D237) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03052 CORO6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20002 Coro6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26505 Coro6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CORO6 MGD MGI:2183448
Felis catus CORO6 VGNC VGNC:61106
Rattus norvegicus CORO6 RGD RGD:708560
Macaca mulatta CORO6 VGNC VGNC:99138
Canis familiaris CORO6 VGNC VGNC:39531
Bos taurus CORO6 VGNC VGNC:27625
Others CORO6 NCBI