MS4A3 - membrane spanning 4-domains A3 Gene

Also Known as HTM4; CD20L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 932

About MS4A3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:60,056,665-60,071,115 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 93 orthologues and 16 paralogues. Restricted expression toward bone marrow (RPKM 168.2).

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

MS4A3 Products (3)

mRNA Protein Name
NM_001031666.2 NP_001026836.1 membrane-spanning 4-domains subfamily A member 3 isoform c
NM_001031809.2 NP_001026979.1 membrane-spanning 4-domains subfamily A member 3 isoform b
NM_006138.5 NP_006129.4 membrane-spanning 4-domains subfamily A member 3 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15671017 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A3 Protein Structure

CD20

CD20: CD20-like family (50 - 196)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

membrane-spanning 4-domains subfamily A member 3

  • CD20 antigen homolog

MS4A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MS4A3 Q96HJ5 TEX264 Homo sapiens Q9Y6I9
Complementation
32296183
Intra
MS4A3 Q96HJ5 TEX264 Homo sapiens Q9Y6I9
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 SLC5A4 Homo sapiens Q9NY91
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 SLC22A14 Homo sapiens Q9Y267
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 SLC22A14 Homo sapiens Q9Y267
Complementation
32296183
Intra
MS4A3 Q96HJ5 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 ATP6V0B Homo sapiens Q99437
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra
MS4A3 Q96HJ5 CCDC167 Homo sapiens Q9P0B6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 22

  • MRD22

  • Mental Retardation, Autosomal Dominant 22

  • Autosomal Dominant Non-Syndromic Intellectual Disability 22

  • Distal Monosomy 1q

  • Autosomal Dominant Intellectual Developmental Disorder 22

  • Autosomal Dominant Mental Retardation 22

  • Distal Deletion 1q

  • Monosomy 1qter

  • Telomeric Deletion 1q

  • Mental Retardation, Autosomal Dominant, Type 22
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08701 MS4A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20993 Ms4a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27510 Ms4a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MS4A3 RGD RGD:1310598
Mus musculus MS4A3 MGD MGI:2158468
Bos taurus MS4A3 VGNC VGNC:58392
Others MS4A3 NCBI