SLC22A14 - solute carrier family 22 member 14 Gene

Also Known as OCTL2; OCTL4; ORCTL4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9389

About SLC22A14

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,278,832-38,318,575 (from NCBI)

This gene has 4 transcripts (splice variants), 482 orthologues and 22 paralogues. Restricted expression toward testis (RPKM 3.4).

Summary

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SLC22A14 Products (2)

mRNA Protein Name
NM_001320033.2 NP_001306962.1 solute carrier family 22 member 14
NM_004803.4 NP_004794.2 solute carrier family 22 member 14

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables riboflavin transmembrane transporter activity IDA
IDA: Inferred from direct assay
33882315 GOA
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
33882315 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A14 Protein Structure

Sugar_tr

Sugar_tr: Sugar (and other) transporter (189 - 569)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 14

  • organic cation transporter-like 4

SLC22A14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC22A14 Q9Y267 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
Intra
SLC22A14 Q9Y267 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Benign Epilepsy With Centrotemporal Spikes

  • Rolandic Epilepsy

  • Benign Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13067 SLC22A14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC22A14 MGD MGI:2685974
Felis catus SLC22A14 VGNC VGNC:68654
Canis familiaris SLC22A14 VGNC VGNC:46275
Rattus norvegicus SLC22A14 RGD RGD:1306470
Bos taurus SLC22A14 VGNC VGNC:34722
Macaca mulatta SLC22A14 VGNC VGNC:77594
Others SLC22A14 NCBI