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Cat. No.: HY-101303

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5-MCA-NAT

5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP.

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CAS No.: 190277-13-5
화학식: C₁₄H₁₇N₃O₃
분자량:275.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

5-MCA-NAT Chemical Structure

CAS No.: 190277-13-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Melatonin MT3 receptor^[1]

All Melatonin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	100 nM Compound: MCA-NAT	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	[PMID: 18372181]
HEK293	IC₅₀	4 μM Compound: MCA-NAT	Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells	[PMID: 18372181]

Chemical Information

CAS No. 190277-13-5
분자량 275.30
화학식 C₁₄H₁₇N₃O₃
SMILES

O=C(NC1=CC2=C(NC=C2CCNC(C)=O)C=C1)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lucchelli A, et al. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol. 1997 Aug;121(8):1775-81. [Content Brief]

[2]. Serle JB, et al. Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes. J Glaucoma. 2004 Oct;13(5):385-8. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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5-MCA-NAT

High-Throughput Bioactive Compound Library

All Melatonin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

5-MCA-NAT Related Classifications

HY-101303 Related Classifications