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Cat. No.: HY-120484

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A-1048400

A-1048400 is an orally active and selective calcium channel inhibitor with an IC₅₀ value of 1.4 μM for N-type channels, 1.2 μM for T-type channel. A-1048400 inhibits neurotransmitter release and reduces membrane hyperexcitability, exerting potent analgesic activity. A-1048400 is promising for research of neuropathic pain (e.g., pain induced by spinal nerve ligation and chronic constriction injury).

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CAS No.: 1219624-62-0
화학식: C₃₆H₃₇N₃O₂
분자량:543.70

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

A-1048400 Chemical Structure

CAS No.: 1219624-62-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Calcium Channel Isoforms :

Chemical Information

CAS No. 1219624-62-0
분자량 543.70
화학식 C₃₆H₃₇N₃O₂
SMILES

O=C1N(CC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)CCCC1(C5=CC=CC=C5)C6=CC=CC=C6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Scott VE, et al. A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats. Biochem Pharmacol. 2012 Feb 1;83(3):406-18. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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A-1048400

All Calcium Channel Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

A-1048400 Related Classifications

HY-120484 Related Classifications