Atropine hydrobromide
Based on 26 publication(s) in Google Scholar
Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia.
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- CAS No.: 6415-90-3
- 화학식: C17H24BrNO3
- 분자량:370.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Atropine hydrobromide
More- Cell. 2025 Nov 26;188(24):6754-6773.e29. [Abstract]
- Cell Metab. 2022 Dec 6;34(12):1999-2017.e10. [Abstract]
- Cell Stem Cell. 2026 May 15:S1934-5909(26)00158-X. [Abstract]
- Kidney Int. 2026 Jan 19:S0085-2538(26)00008-6. [Abstract]
- Sci Adv. 2025 Dec 5;11(49):eadw7972. [Abstract]
- Small. 2026 Jan 21:e06988. [Abstract]
- J Neuroinflammation. 2026 May 25. [Abstract]
- J Hazard Mater. 2024 Nov 5:479:135690. [Abstract]
- J Hazard Mater. 2024 Mar 5:465:133248. [Abstract]
- Food Chem. 2022 Nov 30:395:133593. [Abstract]
- J Transl Med. 2025 Jan 23;23(1):112. [Abstract]
- Cell Rep. 2026 Mar 24;45(3):117086. [Abstract]
- Cell Rep. 2022 Mar 8;38(10):110468. [Abstract]
- J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
- Eur J Pharmacol. 2024 Nov 15:983:176954. [Abstract]
- Front Pharmacol. 2020 Jul 31:11:1038. [Abstract]
- Insect Biochem Mol Biol. 2026 Sep:194:104634.
- Am J Physiol Renal Physiol. 2024 Nov 1;327(5):F885-F898. [Abstract]
- Cardiovasc Drugs Ther. 2025 Apr 7. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Arch Oral Biol. 2023 Jan:145:105586. [Abstract]
- Can J Physiol Pharmacol. 2020 Oct;98(10):725-732. [Abstract]
- J Biosci. 2021:46:90. [Abstract]
- Research Square Print. 2023 Feb 7.
- Research Square Print. December 16th, 2022.
- Research Square Preprint. 2022 Mar.
Customer Validation & Images
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Histological Imaging/Staining
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WB
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In Vivo Efficacy Study
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WB
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Bio/Physico-chemical Assay
Biological Activity
제품 설명
IC50 & Target
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mAChR4 |
In Vitro
Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) hydrobromide inhibits ACh-induced relaxations in human pulmonary veins[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:White-footed mice (Peromyscus sp.)[2]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; once, for 40 minutes
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Result:Increased heart rate was a decrease in cardiac arrhythmia.
Chemical Information
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CAS No. 6415-90-3
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분자량 370.28
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화학식 C17H24BrNO3
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SMILES
O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C(CO)C3=CC=CC=C3.Br
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Synonyms
Tropine tropate hydrobromide; DL-Hyoscyamine hydrobromide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (26)
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Journal Impact Factor
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Most Recent
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Cell
2025 Nov 26;188(24):6754-6773.e29. PMID: 41138728 -
Cell Metab
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies. [Abstract]2022 Dec 6;34(12):1999-2017.e10. PMID: 36395769 -
Cell Stem Cell
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. [Abstract]2026 May 15:S1934-5909(26)00158-X. PMID: 42143017 -
Kidney Int
2026 Jan 19:S0085-2538(26)00008-6. PMID: 41565024 -
Sci Adv
EphB1-NR2B receptor signaling in glutamatergic neurons of the ventroposteromedial thalamic nucleus regulates emergence from anesthesia. [Abstract]2025 Dec 5;11(49):eadw7972. PMID: 41348875 -
Small
A Balloon Electrochemical Sensor for Conformal Interfacing With Intestinal Wall and Real-Time Monitoring of Serotonin Release. [Abstract]2026 Jan 21:e06988. PMID: 41563114 -
J Neuroinflammation
PVNOXT regulates acinar cell-mediated inflammatory response via DMVACh projections to the acinar cell. [Abstract]2026 May 25. PMID: 42186091 -
J Hazard Mater
β-ionone inhibits the grazing of Daphnia sinensis by reducing the activity of acetylcholinesterase. [Abstract]2024 Nov 5:479:135690. PMID: 39255669 -
J Hazard Mater
β-cyclocitral, a novel AChE inhibitor, contributes to the defense of Microcystis aeruginosa against Daphnia grazing. [Abstract]2024 Mar 5:465:133248. PMID: 38147752 -
Food Chem
Screening of bioactive flavour compounds targeting muscarinic-3 acetylcholine receptor from Siraitia grosvenorii and evaluation of their synergistic anti-asthmatic activity. [Abstract]2022 Nov 30:395:133593. PMID: 35792488 -
J Transl Med
Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth. [Abstract]2025 Jan 23;23(1):112. PMID: 39849539 -
Cell Rep
2026 Mar 24;45(3):117086. PMID: 41831232 -
Cell Rep
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch. [Abstract]2022 Mar 8;38(10):110468. PMID: 35263588 -
J Ethnopharmacol
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+ antagonism and maintaining mitochondrial function. [Abstract]2024 Jan 30;319(Pt 2):117192. PMID: 37734472
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Representative images of TTC-stained brain coronal sections of rats.
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Western blot results of signal pathways.
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Statistical results of neurological score by mNSS.
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Statistical results of Western blot in AKT/p-AKT.
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Eur J Pharmacol
Activation of Piezo1 channels enhances spontaneous contractions of isolated human bladder strips via acetylcholine release from the mucosa. [Abstract]2024 Nov 15:983:176954. PMID: 39237075
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Nov 15:983:176954. [Abstract]
Yoda1-induced ATP release was significantly attenuated in the presence of Atropine (1 μM).
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Front Pharmacol
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. [Abstract]2020 Jul 31:11:1038. PMID: 32903813 -
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Am J Physiol Renal Physiol
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats. [Abstract]2024 Nov 1;327(5):F885-F898. PMID: 39298550 -
Cardiovasc Drugs Ther
Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Heart Failure with Preserved Ejection Fraction Through Regulating Macrophage Polarization Mediated by Alpha7nAChR. [Abstract]2025 Apr 7. PMID: 40193005 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Arch Oral Biol
Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation. [Abstract]2023 Jan:145:105586. PMID: 36410162 -
Can J Physiol Pharmacol
2020 Oct;98(10):725-732. PMID: 32516556 -
J Biosci
M1 macrophages-derived exosomes miR-34c-5p regulates interstitial cells of Cajal through targeting SCF. [Abstract]2021:46:90. PMID: 34544909 -
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Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
[1]. McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8. [Content Brief]
[2]. Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57. [Content Brief]
[3]. Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. [Content Brief]
[4]. Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Atropine hydrobromide Related Classifications
HY-B1205B Related Classifications
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